Microvascular complications and foot care: standards of medical care in diabetes Visfatin and omentin are 2 other adipokines produced particularly by intra-abdominal adipodity that were originally thought to be possible contributors to insulin resistance; however, there is no strong evidence at this stage that either plays an important role in modulating insulin action in humans 64 see Section VI. Nadeau, D. The perils of portliness: causes and consequences of visceral adiposity. Table 6. You can also search for this author in PubMed Google Scholar.
Albright hereditary osteodystrophy: AD inheritance, associated with obesity, short stature, PTH resistance, and skeletal defects.
There were no significant differences in Table 1 between diabetic women and diabetic men. Journal List Nutr Diabetes v.
Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum.
Gender differences of visceral fat area for predicting incident type 2 diabetes in Koreans. IL Acute release from exercising muscle likely to enhance insulin sensitivity.
The method of assessment effect was not abdominal adiposity diabetes for detecting differences in subcutaneous adiposity distribution. Data without publication bias is expected to generate a funnel shaped scatter plot that follows the distribution of the effect sizes. Rissanen, Y.
Dietary sugars and cardiometabolic risk: systematic review and meta-analyses of randomized controlled trials of the effects on blood pressure and lipids. Gender differences of visceral fat area for predicting incident type 2 diabetes in Koreans. Associations between abdominal obesity indices and the prevalence of CVD. Deaths where the specific cause was unavailable were not included in the cause-specific analysis. Haarbo, U. Mutations in genes encoding key regulators of appetite in the hypothalamus, including leptin, the leptin receptor, pro-opiomelanocortin, prohormone convertase, the melanocortin 4 receptor MC4Rand others, have been identified in humans with severe, early-onset obesity Table 4.
Both measures are indexed by dividing by the mean circumference for the lowest BMI quintile of abdominal adiposity diabetes subjects. These proposed mechanisms need to be evaluated further in intervention studies. Stray-Gundersen, B. Chessler, E. A total of effect sizes were extracted from 41 studies, 54 effect sizes for visceral adiposity, and 47 effect sizes for subcutaneous adiposity. Suwa, H.
Journal of Obesity
Proceedings of National seminar on 'Status, problems and prospects of jaggery and khandsari industries of India. Kober, A. The mean age of the participants ranged from 28 to 74 years.
Bray, K. Kim, S. Martel, J. Haffner5 and Allan Abdominal adiposity diabetes. Favorable effects of walking levels on glycemic control have been hypothesized to be mediated through reductions in abdominal adiposity, but this has not been well studied. Kuller, and S.
A subcohort of aviposity with a confirmed diagnosis of diabetes mellitus at study entry was defined. In addition, the abdominal adiposity diabetes role of perivascular fat has already been discussed Section III. It has been suggested that estrogen depletion in the postmenopausal period may result in the increased deposition of body fat in the intra-abdominal region because administering hormone replacement therapy to postmenopausal women prevented an increase in abdominal fat Reunanen, and P. A contrast test for types of health conditions moderator effect was 2. Visceral fat accumulation is associated with increased plasma sphingosinephosphate levels in type 2 diabetes mellitus. Longer-term moderate caloric restriction with greater weight loss was not associated with a preferential visceral fat loss reviewed in detail in Ref.
Westerbacka, A. Furthermore, the results of this research weight loss tips in urdu by zubaida aapa chapli have been influenced by the different characteristics of the prediabetic group or other confounding factors. Further meta-analysis that incorporates the relative risk or odd ratio effect sizes is needed to explicate the causal association between diabetes and abdominal adiposity distribution. Lee, R. Kainulainen, M.
Recognition of the contribution of abdominal and ectopic lipid, rather than an individual's excess weight as measured by body mass index [BMI]to insulin resistance and cardiometabolic risk has led to the evolution of technologies to accurately and noninvasively define these depots Table 1. General characteristics according to sex-specific quintiles of body mass index are shown in Table 1. Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide.
Aasen, H. In summary, the various adipose depots in humans appear to abdominal adiposity diabetes insulin action first by influencing the tissue supply of fatty acids and their metabolically active derivatives, DAGs, LCACs, and ceramides. Lee, and K. Therefore, these data alone are relatively unhelpful in determining insulin resistance causation. Heymsfield, and R. Association of subcutaneous and visceral adiposity with albuminuria: the Framingham Heart Study.
Steven M. The abdominal adiposity diabetes study is limited by its cross-sectional nature, and potentially by its sample size. Goodpaster, F. In contrast, two older studies from s found that subcutaneous adiposity is related more closely to diabetes in men, as opposed to visceral adiposity [ 8687 ].
Nam, K. Bythis global disease is expected to be the seventh most common cause of death [ 78 ]. C : Waist intercept, DM 0. Hayashi, E. Using the approach described previously, age, ethnicity and sex were determined to be statistically important confounders and as such they were included in all models. The subcutaneous adiposity pooled effect size of 0.
RESEARCH DESIGN AND METHODS
Tremblay, and C. Published weight loss tips in urdu by zubaida aapa chapli Jan View at: Google Scholar R. Among the subjects mean age 60 years; mean BMI In contrast, whereas higher step counts are associated with a lower A1C, roughly one-third of this association is accounted for by reductions in abdominal adiposity, according to our models.
Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians. Email alerts Article activity alert. Fujioka, P. McKenney JM. Adiponectin and adiponectin receptors. Therefore, these data alone are relatively unhelpful in determining insulin resistance causation. Chronic hepatitis C is associated with peripheral rather than hepatic insulin resistance.
In men, abdominal fat is an important adipose tissue depot regulating muscle sympathetic nerve activity, whereas in women, despite higher total body fat, this relationship is absent Chronic hepatitis C is associated with peripheral rather than hepatic insulin resistance. PubMed Google Scholar 5. Effects of short-term high-fat, high-energy diet on hepatic and myocardial triglyceride content in healthy men. Imbalanced dietary profile, anthropometry, and lipids in urban Asian Indian adolescents and young adults.
Journal of Obesity
Ethnicity, obesity and the metabolic syndrome: implications on assessing risk and targeting intervention. WHO Expert Consultation. Tina L. HIV lipodystrophy is associated with a substantially increased diabetes risk and an increase in cardiovascular events commensurate with the adverse metabolic profile, particularly lipids
Virtanen, P. Two recent studies in severely obese individuals have reported significant associations between liver DAG and suppression of endogenous glucose output abdominal adiposity diabetes hyperinsulinemic clamp or the surrogate HOMA-IRbut no association with ceramide accumulation. Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy. Haffner, S. Stray-Gundersen, B. Carr, K. The suppression of LPL activity results in reduced uptake of fatty acids and triglyceride accumulation in adipocytes.
Freeman, R. Because these are idabetes risk factors, our observations point to the potential to ameliorate the loss of cardiovascular protection in diabetic women. With progression to type 2 diabetes, fasting blood glucose and glucose tolerance response become even higher [ 10 ]. Evidence suggests that visceral adiposity has greater implications for diabetes than other fat depots. Gaborit, F. Troost, T.
Goodpaster, S. Gray, K. As shown in Table 3further adjustment for apoB abolished the significance of the sex-diabetes interaction of each of the other cardiovascular risk measures. View at: Google Scholar A.
Our study highlights the importance of abdominal adiposity as a possible determinant of A1C. Also, the proportion of those with impaired glucose regulation did not differ between nondiabetic men and women. For women, although the average value for LDL cholesterol in diabetic women was 5.
Ye et al. Kanaya, T. A language and environment for statistical computing. All analyses were conducted using the R statistical package.
Gender effects on central fat distribution are well known since men tend to deposit adipose diabbetes in the abdomen, whereas women are prone to the accumulation of adiposity in the gluteal-femoral area [ 20 ]. Nutr Res ; 12 : — Moreover, height is inversely related to overall mortality Diabetes risk prediction model for non-obese Asian Indians residing in North India using cut-off values for pancreatic and intra-abdominal fat volume and liver span.
At present, computed tomography CT and magnetic resonance imaging MRI are abdominal adiposity diabetes advanced instruments of choice to quantify central obesity, as both identify the volumes of visceral and subcutaneous adipose tissue [ 29 — 31 ]. Preliminary pedometer indices for public health. Try out PMC Labs and tell us what you think. Current tobacco use, no. The variations of the adipose distribution were greater for visceral adiposity than other types of adipose tissues, in both men and women [ 80 ]. Table 1.
J Hepatol. Dietary abdominal adiposity diabetes and carbohydrates differentially alter insulin sensitivity during caloric restriction. Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating the glomerular filtration rate in multiple ethnicities. Cardiovasc Diabetol. Kainulainen, M. Neck circumference as an independent indicator of visceral obesity in a Chinese population.
MATERIALS AND METHODS
Two other cohort studies demonstrated weight loss tips in urdu by zubaida aapa chapli a high body mass index was related to increased mortality 1418 diabtes coronary heart disease A number of possible mechanisms account for the observed resistance of germ-free mice to diet-induced obesity. Receive exclusive offers and updates from Oxford Academic. Tropomycin-related kinase B deficiency: rare syndrome associated with obesity, developmental delay, hyperactivity, reduced pain sensation, and impaired short-term memory. Robins et al.
Further testing the oxidative stress markers such as malondialdehyde and advanced oxidation protein product levels in the plasma samples of visceral obesity patients should be considered in the future. Influences of gender addiposity the interaction between sympathetic nerve traffic and central adiposity. Overall, men and women with diabetes were involved in the basal analyses. Am J Cardiol. The pattern observed for measures of abdominal adiposity was similar to the one seen for men, although associations in general tended to be slightly weaker. Garg, R. The unique association between NC and the prevalence of CCA plaque NC has been considered a marker of upper body subcutaneous fat deposits and a simple and valuable screening tool for identifying individuals with obesity [ 1114 ].
The association diabetes the quartiles of NC and the prevalence of CVD remained significant in men, rather than in women, although the associations between the quartiles of NC and the prevalence of CCA plaque remained significant in both men and women Additional file 2 : Table S2.
Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.
Superior to anthropometry and BIA. Garg, R. However, these gender differences in body diabetes may not be related directly to the degree of visceral and subcutaneous adiposity. Muscles, exercise and obesity: skeletal muscle as a secretory organ. It is possible that reinnervation of adipose tissue after transposition disrupts the autonomic balance, resulting in the metabolic changes observed.
Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLPdriven improvement of gut permeability. Influence of endurance exercise training and abdominal adiposity diabetes on intramyocellular lipid and mitochondrial ultrastructure, substrate use, and mitochondrial enzyme daibetes. MRI and CT are also able to quantify liver fat, although CT is not accurate for mild liver fat infiltration 30and MRI techniques other than using MRS of liver fat measurement are still experimental and require further evaluation. Traditional anthropometric measurements used to assess risk for diabetes [ 23 ] that indicate central obesity include waist circumference, sagittal abdominal diameter, waist-to-hip ratio, waist-to-height ratio, and skinfold thicknesses [ 23 — 25 ].
This indicates that the differences in associations diabetes we adiposlty observed between diabetics and nondiabetics are probably caused by differences in absolute levels of adiposity. Interestingly, it has been possible to compare US Pimas to an ethnically and genetically similar population in Mexico with less obesity and diabetes, and substantially different lifestyle; the greater insulin resistance of the US Pimas was accounted for in large part but not fully by their degree of obesity, suggesting that lifestyle, particularly the degree of physical activity, is an important independent contributor to insulin sensitivity Sex differences in African-Americans regarding sensitivity to insulin's glucoregulatory and antilipolytic actions. Kelley, F. Hegazi, L.
The value for testing, if at least one of the four elements CT and MRI in abdominal adiposity diabetes and adipposity adiposity differs from zero, yielded significant results of Three contrast tests independently examined the significance of visceral and subcutaneous adiposity volumes and assessed the significant differences between visceral and subcutaneous adiposity. Abstract Excess fat in the abdomen can be classified generally as visceral and subcutaneous adiposity. Sniderman 6. Lancet : —, [ PubMed ] [ Google Scholar ]. Goodpaster, S. Thus, a meta-analysis was conducted to explore possible disparities of the abdominal adiposity distribution between these two groups.
In both hepatitis C and hypobetalipoproteinemia there is alteration of lipoproteins and lipid metabolism, so it seems likely that metabolically active lipid molecules see Section VI. Neck circumference and future cardiovascular events in a high-risk population—a prospective cohort study.
The cutoff point for the two-tailed test with 0.
Self-reports obtained at baseline were confirmed by additional information sources, which varied by study center and include the following: contact with a medical practitioner, self-reported use of diabetes-related medication e.
Ben-Shlomo et al.
Diabetologia ; 42 : — Advance article alerts. NC has been considered a marker of upper body subcutaneous fat deposits and a simple and valuable screening tool for identifying individuals with obesity [ 1114 ]. Studies using positron emission tomography. PTEN mutations as a cause of constitutive insulin sensitivity and obesity. Center and age at enrollment in 1-year categories were entered as stratum variables to control for differences in questionnaire design, follow-up procedures, and other nonmeasured center effects. Because the measurements were highly correlated in this study population, adjustment may induce collinearity.
How to prevent the microvascular complications of type 2 diabetes beyond glucose control. All prices are NET prices. Dietary sugars and cardiometabolic risk: systematic review and meta-analyses of randomized controlled trials of the effects on blood pressure and lipids. Nutrient intake, body composition, blood cholesterol and glucose levels among adult Asian Indians in the United States. J Biol Chem. Pancreatic steatosis is a relatively new clinical definition, and studies that evaluate pancreatic fat by MRS in humans are emerging. PTEN mutations as a cause of constitutive insulin sensitivity and obesity.
Issue Section:. The newly recognized presence of brown fat in abdominal adiposity diabetes is interesting, and it could clearly contribute to increased metabolic rate, fat oxidation, and thereby insulin sensitivity. The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. About this article.
Alterations in gut microbiota in obesity can result in altered fatty acid metabolism and composition in adipose tissue and liver in mice — and may also modulate gut-derived peptide secretion including peptide YY and glucagon-like peptide 1 GLP-1 secretion, impacting on gut transit time, energy harvest, and satiety ,
View at: Google Scholar R. Tylavsky, and S.
Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians. Revised : 01 April
Fasting plasma free fatty acids FFAs were highest in diabetic women. It is adipossity that overaccumulated visceral fat tends to act as a malfunctional adiposity that induces excess storage of ectopic fat muscle, epicardial, and liver fats [ 17 ]. Of importance, the key findings were consistent across the three different ethnic groups in IRAS. The waist-to-hip ratio WHR was calculated by dividing the waist circumference by the hip circumference. However, diabetic women had higher apoB than diabetic men. McKolanis, R.
Pedometers A, B abdominal adiposity diabetes C were then mailed to our study center in a prepaid, pre-addressed and padded courier envelope. The equations and methods that were incorporated in the analyses were obtained from The Handbook of Research Synthesis and Meta-Analysis [ 74 ]. Boyko, W. All of these findings were confirmed by the differences observed in LDL particle count. Cardiovascular risk factors.
Consequently, abnormal free fatty acid metabolism may trigger dysfunctional release of adipokines [ 17 ]. Wurtman, N. Glucoregulatory and metabolic response to exercise in obese noninsulin-dependent diabetes. National Center for Biotechnology InformationU.
Medications That Promote Adiposity. Open in new tab Download slide. Obes Surg. Article Contents Abstract. Of note, associations in these studies were not adjusted for other anthropometric measurements. Shofer, E.
The present meta-analysis explored gender as a moderator that influences the degree of central obesity. To further investigate the adiposity type-specific moderator effect of type of health conditions of treatment group, -statistics was acquired for the visceral and subcutaneous adiposity volume effects. Moreover, height is inversely related to overall mortality J Am Coll Nutr ; 29 : 81— Ross, J.
The degrees dibetes freedom were acquired by subtracting the number of effect parameters visceral and subcutaneous adiposity from the number of effect sizes retrieved from the screening process. The mean age of the participants ranged from 28 to 74 years. TABLE 3 Baseline measures with significant demographically adjusted interaction by sex and diabetes status additionally adjusted as indicated. Our findings provide quantification of the associations of decreasing waist size and increasing daily step counts on A1C levels among adults treated for type 2 diabetes. Shin, S.
Regional intra-subject variability in abdominal adiposity limits usefulness of computed tomography. Two risk-scoring systems for predicting incident diabetes mellitus in U.
The mechanism of increased secretion of apoB particles is multifactorial, but increased fatty acid flux to the liver is one of the key components
Table 1 General characteristics of all male participants by diabetic complications Full size table.
Clearly, when long-term energy intake is greater than energy expenditure, adiposity will increase and vice versa. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Kim Overvad. Biochem Biophys Res Commun. The relationship between generalized and abdominal obesity with diabetic kidney disease in type 2 diabetes: a multiethnic asian study and meta-analysis.
Am J Physiol Cell Abdominal adiposity diabetes. Supplementary information. Adiopsity aerobic exercise and weight loss: a systematic review and meta-analysis of randomized controlled trials. Relationships between insulin sensitivity and measures of body fat in asymptomatic men and women. CT is easily accessible, but it subjects individuals to small but significant amounts of radiation.
All diavetes measures—waist circumference, hip circumference, waist-to-hip ratio WHRand BMI—were significantly higher in both diabetic groups compared with their nondiabetic counterparts. Leonetti, and L. The mechanism of increased secretion of apoB particles is multifactorial, but increased fatty acid flux to the liver is one of the key components In fact, adjustment for daily step counts resulted in only small attenuations of the associations between anthropometric parameters and A1C. The risks of being diagnosed with diabetes are critical, as it is linked to heart disease, blindness, kidney failure, retinopathy, limb amputation, and other physical ailments [ 910 ]. Subsequently, being healthy versus diabetic was identified as one of the significant covariates suggesting that being diabetic is one of the critical factors in possessing higher amounts of visceral adiposity [ 80 ]. Abate, A.
Bergstrom, D. The significance of the effects of visceral and subcutaneous adiposity was evaluated by computing [ 74 ]. View at: MathSciNet K. The associations of these anthropometric measures with A1C were only marginally decreased by adjustment for daily step counts. Bergeron et al.
Pima Indians with normal glucose tolerance. Nevertheless, abdominal sc fat, particularly its deep layer, may have characteristics intermediate between intra-abdominal and other sc fat discussed under Section III.
This significant gender moderator effect on visceral adiposity might be explained by abdominal adiposity diabetes age of the dabetes participants since a number of the subjects consisted of older women, who might be in their menopausal stage. Moreover, there was no significant increase in the proportion of women with an elevated LDL cholesterol.
On the other hand, leptin and adiponectin are clearly important players that should act to ameliorate obesity and insulin resistance but fail to do so—adiponectin because its secretion is paradoxically reduced in obesity, and leptin because of the phenomenon of leptin resistance.
This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Joanisse, Abdominal adiposity diabetes. A number of possible mechanisms account for the observed resistance of germ-free mice to diet-induced obesity. Robins et al. Nutrition ; 33 : — BMI was calculated as weight in kilograms divided by squared height in meters. In contrast to the protection against obesity conferred by a microbe-free gut, in animal models of obesity, an altered microbiota composition has been associated with the development of obesity, insulin resistance, and diabetes through several mechanisms.
Both ceramides and DAGs have been reported to impair insulin action in muscle and liver cells. All the associations were independent of BMI. Endocr Rev. In order to reduce the heterogeneity, the 55 retrieved studies were then subject to exclusion criteria of using duplicate data, being subjects under 19 years, or being diagnosed with other types of diabetes type 1 diabetes mellitus, gestational diabetes or on hemodialysis. Rissanen, Y. Arterioscler Thromb Vasc Biol.
Miyazaki, M. Sex differences in the relation of visceral adipose tissue abdominal adiposity diabetes to total body fatness. Correlations affected by age and ethnicity Unexpected evidence for active brown adipose tissue in adult humans. Roepstorff et al and others have shown a net reduction in IMTG during prolonged submaximal exercise only in women. The suppression of LPL activity results in reduced uptake of fatty acids and triglyceride accumulation in adipocytes. Cell Host Microbe.
Diabetes accounted for 3. Determination of thermally induced trans-fatty acids in soybean oil by attenuated total reflectance fourier transform infrared spectroscopy and gas chromatography analysis. Klopfenstein, M.
Relationships of circulating sex hormone-binding globulin with metabolic traits in humans. Lucknow Wurtman, N. Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and surgical management. Kober, A. These associations seemed to be independent from general obesity and were nonlinear for men.
Figure 2. Yoshiyama, Y. Swisher et al. The waist-to-hip ratio WHR was calculated by dividing the waist circumference by the hip circumference. The results of -tests for visceral and subcutaneous effect sizes were
Abbreviations: AD, autosomal dominant; AR, autosomal recessive. Men in the highest quintile had a higher alcohol consumption, whereas women with a high body mass index had a lower alcohol consumption and were also less likely to be a current smoker compared with leaner women. The effect size estimate for each study for visceral and subcutaneous adiposity was computed by dividing the differences between the mean values of the abdominal adiposity volumes of the control and treatment groups by the square root of the pooled sample variance. Obes Res.
Ethnicity, obesity and the metabolic syndrome: implications on assessing risk and targeting intervention.
However, diabetic populations had greater visceral abdominal adiposity diabetes intermuscular adipose tissues and less subcutaneous adipose tissue than the healthy controls when the differences in covariates ethnicity, gender, being diabetic or healthy, weight, height, age, and interaction of these factors were adjusted [ 80 ].
In contrast, single-gene or monogenic obesity disorders result in severe early-onset obesity and insulin abdominal adiposity diabetes, although the latter is usually at the level expected from the degree of adiposity of the affected individual. J Clin Endocrinol Metab. Abdominal fat and insulin resistance in normal and overweight women: direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM. Data not available. PTEN mutations as a cause of constitutive insulin sensitivity and obesity.
However, these tips urdu differences in body shape may not be related directly to the degree of visceral and subcutaneous adiposity. Traditional anthropometric measurements used to assess risk for diabetes [ 23 ] that indicate central obesity include waist circumference, sagittal abdominal diameter, waist-to-hip ratio, waist-to-height ratio, and skinfold thicknesses [ 23 — 25 ]. After feeding, fatty acid uptake is higher in abdominal adipose tissue relative to gluteal or femoral in both men and women. The risks of being diagnosed with diabetes are critical, as it is linked to heart disease, blindness, kidney failure, retinopathy, limb amputation, and other physical ailments [ 910 ]. Because the measurements were highly correlated in this study population, adjustment may induce collinearity. Hull et al.
Early lifestyle intervention in patients with non-insulin-dependent diabetes mellitus and impaired glucose tolerance. Kuk, T. Peeters, M.
Egger, G. Among 54 visceral adiposity effect sizes, 38 effect sizes were measured via CT and 16 effect sizes were abdominal adiposity diabetes by MRI. Resnick et al. Wang, L. Residual plots of the most representative models were examined to verify that the assumptions of linear regression were met. Rejecting the statistic indicates that the amount of visceral and subcutaneous adiposity volumes significantly differ among groups.
At recruitment, participants of this prevalent diabetes cohort had a mean age of Revised : 01 April abdominal adiposity diabetes Sex differences in the relation of visceral adipose tissue accumulation to total body fatness. Fujimoto et al. The superiority of waist-to-height ratio as an anthropometric index to evaluate clustering of coronary risk factors among non-obese men and women. Gender differences of visceral fat area for predicting incident type 2 diabetes in Koreans.
Waist-to-height ratio is the best anthropometric index in association with adverse cardiorenal outcomes in type 2 diabetes mellitus patients. Interestingly, it has been possible to compare US Pimas to an ethnically and genetically similar population in Mexico with less obesity and diabetes, and substantially different lifestyle; the greater insulin resistance of the US Pimas was accounted for in large part but not fully by their degree of obesity, suggesting that lifestyle, particularly the degree of physical activity, is an important independent contributor to insulin sensitivity
Huwe, and B.
Kim, Y. Garg, R. At present, computed tomography CT and magnetic resonance imaging MRI are the adipositg abdominal adiposity diabetes of choice to quantify central obesity, as both identify the volumes of visceral and subcutaneous adipose tissue [ 29 — 31 ]. The mechanism of increased secretion of apoB particles is multifactorial, but increased fatty acid flux to the liver is one of the key components Sites, and E. Journal List Nutr Diabetes v. Identification of confounders Using the approach described previously, age, ethnicity and sex were determined to be statistically important confounders and as such they were included in all models.
Published online Jan The associations of these anthropometric diabetes with A1C were only marginally decreased by adjustment for daily step counts. Pouliot, J. These proposed mechanisms need to be evaluated further in intervention studies. Pedometer accuracy in nursing home and community-dwelling older adults.
The present meta-analysis explored gender as a moderator that influences the degree of central obesity. One or more effect sizes were extracted from the same adiposlty because this research involves a meta-analysis of exploring the multivariate outcomes, visceral and subcutaneous adiposity. This research explored the degree of the central obesity distribution within diabetic and prediabetic groups and conducted comparisons to the nondiabetic group. Adjusting for apoB abolished the significance of the sex-diabetes interaction of each of the other cardiovascular risk factors. There was a 0.
Kanaya, T. Interestingly, a small randomized study of weight loss intervention in obese men and women found an improvement in insulin sensitivity with either calorie restriction or exercise adipposity a concomitant decrease in all DAG species abdominal adiposity diabetes muscle, but the change in ceramide species was intervention-dependent, with 6 of 8 measured species decreasing with exercise and 3 decreasing and 1 increasing with calorie restrictionsuggesting that different ceramide species may be involved in the insulin-sensitizing effect of calorie restriction and exercise and that specific ceramide species may be harmless to insulin sensitivity. Natasha Beretvas supervised the overall data analysis and participated in manuscript preparation. Natasha Beretvas, Jeanne H. PLoS One ; 2 : e Several studies would suggest that this is not the case.
Not only was the average apoB highest in diabetic women, almost one-half of diabetic women had a markedly elevated apoB. Previous studies in this population have adjusted for BMI when evaluating models containing anthropometric parameters such as waist circumference. Descriptions of the other measures used in this analysis have been published 19 The significance of the effects of visceral and subcutaneous adiposity was evaluated by computing [ 74 ].