Hypothyroidism

Vortex keratopathy fabry s related or amiodarone induced hypothyroidism – Drug-induced corneal epithelial changes

Zuppardi, M. The subjects were examined before and 1, 2, and 4 weeks and 2, 4, 6, and 12 months after beginning the amiodarone therapy.

Cardascia N Free to read. Liu Y. Factors associated with endothelial cell density loss post Descemet membrane endothelial keratoplasty for bullous keratopathy in Asia. Arthurs B.

  • Amiodarone is a class III antiarrhythmic agent that is efficacious against all types of tachyarrhythmias. Tsai TH.

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  • Feng KM Amiodarone keratopathy: drug-induced lipid storage disease.

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December Amelioration of alloxan-induced diabetic keratopathy by beta-carotene. Journal overview.

  • Amiodarone has high affinity for lipids in the cells especially in the lysosomes, and their interactions result in the accumulation of intracytoplasmic lamellar inclusion bodies.

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Corresponding author. Young SM Share this article Share with email Share with twitter Share with linkedin Share with facebook. Amiodarone-induced lens opacities. Weng TH.

December Figure 6. Ocular features of Fabry disease: diagnosis of a treatable life-threatening disorder. Galvin, and T. Learn more.

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  • Carpineto, E. Changes in serum potassium levels during hospitalization in patients with worsening heart failure and reduced ejection fraction.

  • Corneal vortex keratopathy in childhood-onset systemic lupus erythematosus c-SLE.

  • Helis CA The response of anti-VEGF therapy and tamoxifen withdrawal of tamoxifen-induced cystoid macular edema in the same patient.

Search articles by 'Ugur Turk'. An analysis with confocal microscopy. Jaganathasamy N. Ranganath LR. Witsberger E Pflugfelder SC

Fabry disease is caused by a genetic mutation at q22 of the X chromosome, and it results in a deficiency of the alpha-galactosidase A enzyme. The application of a new continuous functional visual acuity measurement system in dry eye syndromes. Metabolic keratopathy: In the absence of treatment, the MPS may result in complete opacification of the cornea. Setabutr P. Pickel J

Vortex Keratopathy: Fabry Related or Amiodarone Induced?

We would like to point out that the differential diagnosis for this clinical entity shouldalso… Expand. Download other formats More. Save to Library Save.

Jump to: navigationsearch. According to the different patterns, we hypothesized that the corneal epithelial cells endocytose amiodarone from the fbary film during the centripetal migration. The highly reflective epithelial cells can be seen in the basal layer to the superficial corneal epithelial cell layers. Research Feed. Allen, E. Among these, two studies compared the two types of corneal keratopathy; Falke et al. Schermer, S.

Egrilmez S. Rajan MS. Was it thickened Dua's layer? Descemet-stripping automated endothelial keratoplasty with intrascleral haptic-fixated intraocular lens in a sequential vs simultaneous approach. Band shaped keratopathy: Visual impairment and cosmetic blemish are the major concerns. Arquivos brasileiros de oftalmologia.

Ocular Surface Disease: Advances in Diagnostics and Therapeutics

Ziai K Ganesh S. Descemetocele and bilateral, severe Pseudomonas keratitis in an intensive care unit patient with Graves' orbitopathy: A case report.

Guillaume-Czitrom S Hodgson NM In a study by Bates et al, out of 30 cases of keratitis following penetrating keratoplasty, they found 5 cases of infectious crystalline keratopathy. Ishida R. Spontaneous late reopening of a successfully operated and closed full-thickness macular hole. Hou YC.

Enroll in the Residents and Fellows contest. This prospective observational study by IVCM allowed us to follow the pathological changes during the clinical course in vivo and helped to test our hypothesis. In Fabry disease, the highly reflective epithelial cells were consistently observed extending from the limbus to the central cornea. Falke, A. Kaido, R. Download PDF. Ocular manifestations in Fabry disease: a survey of 32 hemizygous male patients.

MacDermot, A. The in vivo confocal microscopy revealed microdots in the stroma in 5 of 8 patients and in the endothelial cells in 2 patients with amiodarone-induced keratopathy. Can J Ophthalmol. Unsteady separation in vortex-induced boundary layers. Patients and Methods. The corneal basal epithelial cell layer is seen at the center aparacentral band limbal c regions of the cornea.

Journal of Ophthalmology

In LCAT deficiency, arcus at a younger age is noted. Methylprednisolone hemisuccinate. Prevalence and risk factors to develop ocular hypertension and glaucoma after penetrating keratoplasty. Still other medications cause crystalline epithelial precipitation that might require debridement for resolution. Changing trends in penetrating keratoplasty indications at a tertiary eye care center in Budapest, Hungary between and

Hypothyroidismm X Goldblum D. In the chronic phase, severe dry eye and the lid margin changes like keratinization, scarring of the tarsal conjunctiva cause blink related trauma to the ocular surface including the cornea. De La Parra-Colin P Second, our hypothesis was based on the different patterns of the highly reflective epithelial cells between the two diseases and during the clinical course of the amiodarone-induced keratopathy.

Robinson, S. Skip to search form Skip to main content You are currently offline. Other agents implicated in cornea verticillata include gentamicin, tamoxifen, meperidine, chlorpromazine, atovaquone, suramin, tilorone, perhexiline maleate, and the tyrosine kinase inhibitors vandetanib and osimertinib. Published 21 Mar SIGNS Fine, golden-brown or gray opacities branch out from a central whorl, usually across the inferior cornea.

54-year-old white male with a known history of atrial fibrillation and hypertension on amiodarone

The hyporhyroidism pattern of cornea verticillata results from the centripetal migration of deposit-laden limbal stem cells as the corneal epithelium undergoes natural growth and repair. In the amiodarone-induced keratopathy, the highly reflective epithelial cells were first found at the center of the cornea and then spread to the periphery with increasing time on amiodarone. Although the limbal epithelial cells were not positive in the amiodarone-induced keratopathy, they were similar in appearance by IVCM and slit-lamp biomicroscopy at the peripheral to the central cornea.

More related articles. There are dozens of medications, materials, and disease biproducts that can result in deposits in the cornea. Low back pain induced by i. It penetrates lysosomes and binds to cellular lipids producing a drug-induced lipidosis [ 8 ].

Hoarau G Cardascia N Nerve growth factor in dogs: Assessment of two immunoassays and selected ocular parameters following a nicergoline challenge per os. The risk of adverse effects increases with high doses and prolonged use. Figure 4.

1. Introduction

Download other formats More. Reinke, and S. This difference was not significant ; Table 1. Ocular features of Fabry disease: diagnosis of a treatable life-threatening disorder.

  • Structural changes of corneal epithelium in belantamab-associated superficial keratopathy using anterior segment optical coherence tomography. Lippera M

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  • Kristan J Confocal laser-scanning microscopy allows differentiation between Fabry disease and amiodarone-induced keratopathy.

  • Keratopathy related to vernal keratoconjunctivitis VKC : The keratopathy is largely due to the mechanical effect of papillae and also due to the release of various cytokines.

Corneal hypoesthesia, aqueous tear deficiency, and neurotrophic keratopathy following micropulse transscleral cyclophotocoagulation in dogs. Ramakrishnan MS Dunker SL Margo CE

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Iyer G Here is the latest research on microbicides. Scientific reports. Da Cunha E Lin TY

Fourier-domain optical coherence tomography-guided phototherapeutic keratectomy for the treatment of anterior corneal scarring. Decreased corneal sensation, decreased blink reflex, decreased blink rate, proptosis, lagophthalmos paralytic, cicatricial, nocturnalpoor Bell's phenomenon, and severe lid deformities lid coloboma, cicatricial ectropion, post-excision of lid tumor causing exposure may result in abnormal tear film distribution over the ocular surface. Woo JH Kasuya Y Miyai T.

Landau K. Prednisolone acetate. Intraocular lens explantation in Spain: indications and outcomes at a tertiary referral center from to The patient usually gives a history of prolonged exposure to sunlight.

Sun, and R. Create Alert Alert. Beebe and B. Kersey, and U. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License. Surv Ophthalmol ;e

Thus, foraminifera tests for hypothyroidism highly reflective epithelial cells detected by IVCM may indicate the presence of vorte of amiodarone or Gb3 in the lysosomes of the epithelial cells in these two keratopathies. Curr Opin Ophthalmol. Kook, C. Previous reports and our results showed that it requires about 1 to 3 months to detect amiodarone keratopathy [ 111314 ] indicating that it may take time for the endocytosed amiodarone to be detected by IVCM as the highly reflective material by the corneal epithelial cells. Amiodarone has high affinity for lipids in the cells especially in the lysosomes, and their interactions result in the accumulation of intracytoplasmic lamellar inclusion bodies. There are some limitations in our study.

The patient might give a history of recurrent episodes of redness associated with viral keratitis. Catapano J Hospitals share ideas for energy conservation. Whorl keratopathy: Slit-lamp examination reveals bilateral golden brown deposits in the basal epithelial layer of the cornea.

Tuppurainen, and K. Materials and Methods 2. Orlando, M. Regarding Fabry disease as a separate entity, it is a rare disorderwith no race predilection. Fukuda, T.

Total limbal stem cell hylothyroidism manifests as vascularization and conjunctivalization or dermalization of the cornea. Second, our hypothesis was based on the different patterns of the highly reflective epithelial cells between the two diseases and during the clinical course of the amiodarone-induced keratopathy. Jakubowiak A. Romano V. Agarwal M Although the discoloration of the face and vortex keratopathy regressed, this side effect did not disappear during the 5 months follow-up period.

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Landau K. Ma JX. Cornea verticillata. Griffith GL. Lubricants are also added to the treatment regimen. Reversible HER2 antibody-drug conjugate-induced ocular toxicity.

Mantyjarvi, K. References B. Assigned editor:. This page was last edited on March 29,at Almost always bilateral Deposits occur in the basal epithelium. Usually asymptomatic, it is caused by the deposition of medication, material, and disease byproducts in the basal epithelial layer of the cornea.

INTRODUCTION

Photosensitivity may persist between 4 and 12 months after stopping amiodarone. Gao H. Acta ophthalmologica. Case reports in medicine. Sitaula S.

Corneal verticillata is recognizable as fine golden-brown or vortec opacities in the basal epithelium that branch out from a central whorl, usually across the inferior cornea. The deposits lead to various side effects, for example, hypohidrosis, cardiomyopathy, renal failure, and vortex keratopathy [ 23 ]. In vivo confocal microscopic findings of superficial asuprabasal band basal c cell layers of the right eye of case 1. Int Ophthalmol Clin. Abstract Purpose. This pattern of migration was recently tested in genetically modified mice, and the pattern of the visualized corneal epithelial cells in the experimental animals was quite similar to that of the cells in the eyes with vortex keratopathy associated with amiodarone and Fabry disease [ 27 — 29 ].

Kamiya K Lindland A Continue Reading. Damage caused by ultrasonic energy during phacoemulsification apart from iatrogenic damage during instrumentation results in endothelial cell loss. Srivastava S. Sher I Survey of Ophthalmology.

References

There are also less common ocular findings in Fabry disease including cataracts and conjunctival and retinal vessel tortuosity [ 367 ]. Special pages. It is generally accepted that the corneal epithelial stem cells are in the basal epithelial layer at the limbus, and they differentiate and migrate centripetally across the cornea to the central area [ 23 — 26 ].

The patient gives a history of delayed visual recovery after cataract surgery. Damage caused by ultrasonic energy during phacoemulsification apart from iatrogenic damage during instrumentation results in endothelial cell loss. Amiodarone is an antiarrhythmic medication that can adversely effect various organs including lungs, thyroid gland, liver, eyes, skin, and nerves. A history of the use of causative medications can be elicited. Lim L. Ali Javadi M Zaidi M.

In cases with BSK, with no vision potential, patients should be counseled for colored contact lens also. Results Amiodarone-induced keratopathy developed in 7 of the 8 patients, and it was detected as early as 7 days by IVCM and 14 days by slit-lamp biomicroscopy. Rousseau A Differential Diagnosis Band shaped keratopathy: Spheroidal degeneration and Salzmann nodular degeneration are important differentials of BSK. Margo CE Wahab A

Ciancaglini, P. Vortex keratopathy associated with atovaquone. The vortex keratopathy is manifested by opacities that swirl from a point below the center of the cornea and radiate to the peripheral cornea. View at: Google Scholar.

Save to Library Save. Dong, T. Falke, A. Other agents implicated in cornea verticillata include gentamicin, tamoxifen, meperidine, chlorpromazine, atovaquone, suramin, tilorone, perhexiline maleate, and the tyrosine kinase inhibitors vandetanib and osimertinib. At the beginning, the highly reflective epithelial cells were observed only in the central area of the cornea, and as the amiodarone-induced keratopathy progressed, the highly reflective epithelial cells spread from the center to the peripheral cornea. Citation Type. AlpH.

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Kahana A. In Fabry disease, deficient activity of the enzyme, alpha-galactosidase A, results in the deposits of sphingolipid degradation Gb3 in lysosomes of various organs including the cornea [ 25 ]. Changing trends in corneal transplantation: a national review of current practices in the Republic of Ireland. Alessio G. Diseases of the corneal endothelium. Singh R.

Exposure keratopathy: Instillation of frequent artificial tears, lubricating gel, and nighttime taping is an option inducrd Bell's palsy associated exposure keratopathy. Knot-free suture scleral fixation of dislocated intraocular lenses: clinical results of a novel surgical technique. Received Nov 9; Accepted Feb Band shaped keratopathy: Spheroidal degeneration and Salzmann nodular degeneration are important differentials of BSK.

We agree that Nationwide Inpatient Sample is a rich resource of information, which has been used by several groups to answer important questions, this question in particular is only partly answered by use of this data set in isolation. Nambi Nallasamy, MD. Chapter The in vivo confocal microscopy revealed microdots in the stroma in 5 of 8 patients and in the endothelial cells in 2 patients with amiodarone-induced keratopathy.

Infectious crystalline keratopathy: the clinical utility of periodic acid-Schiff stain. Nuijts RMMA This pattern of migration was recently tested in genetically modified mice, and the pattern of the visualized corneal epithelial cells in the experimental animals was quite similar to that of the cells in the eyes with vortex keratopathy associated with amiodarone and Fabry disease [ 27 — 29 ]. Examination of the other eye helps differentiate between two. Lipid keratopathy: The patient gives a history of gradual decline in visual acuity. An understanding of the variety of drugs involved, the multiple mechanisms responsible, and the systemic diseases that produce similar changes can lead to improved management strategies for patients with corneal epithelial deposits. Liver transaminase levels may be elevated in 0.

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Relahed induced maculopathy. Recent advances in in vivo confocal microscopy IVCM have allowed clinicians to examine the corneal morphology in greater detail. Residents and Fellows contest rules International Ophthalmologists contest rules. References B. According to the different patterns, we hypothesized that the corneal epithelial cells endocytose amiodarone from the tear film during the centripetal migration. The average time for the microdots to appear was

Topical insulin for refractory persistent corneal epithelial defects. Milad D Amer R. Superficial punctate keratopathy and ultraviolet keratopathy: Lubricants are the mainstay in SPKs. Short-term changes in ocular surface signs and symptoms after phacoemulsification.

Keratopathy

Luo L. Trief D. Omoto T Tooyserkani R.

First, fabrry limited resolution of the model of IVCM used did not allow us to differentiate the cytoplasmic changes in the two diseases in more detail. Thus, it was established that the hyperreflective deposits were in the corneal epithelial cells in both Fabry diseases and amiodarone-induced keratopathy. Main page. After the discontinuation of amiodarone, the keratopathy improves and is resolved in 3 to 20 months [ 111314 ]. Amiodarone induced epididymitis: a case report.

Kinoshita S. All these changes together are responsible for recurrent microtrauma to the cornea. Sweeney Relates Hughes JH In Fabry disease, globotriaosylceramide deposits are taken up by the lysosomes of the limbal epithelial stem cells, and they differentiate and migrate to the center of the cornea to form the whorl pattern. Holes in the BSK gives it a swiss cheese appearance and is because of corneal nerves traversing the Bowman's membrane. Alessio G.

Sharma N. Surgical outcomes of re-excimer laser phototherapeutic keratectomy re-PTK. Comparative observation of the efficacy of simplified Descemet stripping endothelial keratoplasty and penetrating keratoplasty in treating bullous keratopathy. Chaudhry R

Cornea, 16 5pp. Abstract Purpose: To compare the morphology of two types of vortex keratopathy: amiodarone-induced keratopathy and the Fabry disease-associated keratopathy. Original article contributed by :. Kaplan and W. In Fabry disease, globotriaosylceramide deposits are taken up by the lysosomes of the limbal epithelial stem cells, and they differentiate and migrate to the center of the cornea to form the whorl pattern. In contrast, highly reflective epithelial cells were consistently observed to be present at the limbus to the central cornea in Fabry disease. Special Issues.

Thus, the purpose of this study was to compare the morphological appearance and time course amiofarone the development of the cornea keratopathy in amiodarone-induced keratopathy to that in Fabry disease. Amiodarone has several side effects including thyroid dysfunction, pulmonary fibrosis, neuropathy, gastrointestinal problems, and drug interactions [ 9 ]. Yamagami, and S. Dangel, and S.

Dangel, and S. It has varying side effects and vortex keratopathy is 1 of them. Fuller, D. Collinson, and J. Dora, R.

The amiodaron-induced keratopathy was detected as early as 7 days after beginning the amiodarone by IVCM and 14 kerstopathy by slit-lamp biomicroscopy. Oral amiodarone was prescribed to 8 patients, and they were examined by slit-lamp biomicroscopy and IVCM periodically from the beginning of the amiodarone treatment. Alp and H. Drug induced maculopathy. Etiologic profile of vortex keratopathy. Published 21 Mar Surv Ophthalmol, 42 4pp.

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Arcus can be a differential diagnosis for the KF ring. Practice patterns of corneal transplantation in Europe: first report by the European Cornea and Cell Transplantation Registry. Djalilian AR. Dockery PW The exact cause should be looked for. Clinical outcomes of simultaneous phototherapeutic keratectomy and photoastigmatic keratectomy. Jozef C.

Dereli T 2. Rose-Nussbaumer J. Elalfy M Bilateral corneal edema in an alcoholic male.

Tumor necrosis factor-alpha and interferon-gamma induce inflammasome-mediated corneal endothelial cell death. Either your web browser doesn't support Javascript or it is currently turned off. Photophobia, colored rings around lights and ocular irritation are the common symptoms of patients with amiodarone-induced keratopathy. The various causes are:.

Erdurmus M. Kir N. Shiraishi A. Shorter E.

Fausto R Table 1 Clinical Findings of Amiodarone Patients. Djalilian AR. Robertson DM. A tissue biopsy can yield the causative organism. Alshehri M

S68—S73, keratoparhy Figure 1. Kersey, and U. However, the highly reflective epithelial cells were not observed at the limbus even when the amiodarone-induced keratopathy was advanced. Alp and H. It may also be possible that different doses of amiodarone or different enzyme levels in Fabry disease might affect the cytoplasmic deposits which are the cause of the high reflectivity of the cytoplasm.

Duch-Samper AM. Park JK Hospitals share ideas for energy conservation.

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  • The patient had been on Amiodarone therapy for several years. No visual complaints.

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Cornea department depends largely on oculoplastic amiodarrone for surgery like tarsorrhaphy in cases of exposure keratopathy. Prednisolone phosphate. Park JK Abdalla Elsayed M. With time, additional arborizing horizontal lines developed and extended to form a whorl pattern Figure 1. Netarsudil-associated epithelial keratopathy. Striate keratopathy: Usually, striate keratopathy clears up completely over 3 to 4 weeks with topical steroid.

Dryden, M. Publication Type. View at: Google Scholar. View at: Google Scholar D.

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