Physical signs include an abnormal rate of head growth, frontal bossing of the forehead, widened sutures, and dilated scalp veins. External link. Congenital hypothyroidism. The underlying etiology of thyroid dysgenesis remains largely unknown. Hypophosphatasia polyhydramnios, short, deformed limbs, soft skull.
By law, all newborns are screened in the first few days of life for serious diseases.
There is phenotypic overlap with the cranioectodermal dysplasias Sensenbrenner syndrome; see CED1, If you are concerned that your baby's soft spot has not closed after about 1 year of age, talk to your pediatrician.
Congestive heart failure.
Also, higher doses of l-thyroxine have been associated with higher intelligence quotients at 7 and 8 years of life, especially in the areas of verbal memory and verbal comprehension [ 92 ].
A congenital condition characterized by hypoplasia, absence, or ectopic position of the thyroid gland. A fontanelle can close earlier or later and still be normal. Sundine MJ.
Congenital hypothyroidism can large fontanelle hypothyroidism treatment occur due to genetic defects of thyroxine or triiodothyronine synthesis within a structurally normal gland. Adding selenium-rich foods to your diet is a great way to boost your selenium levels. When the thyroid gland receives a signal called thyroid-stimulating hormone TSHit releases thyroid hormones into the bloodstream. In the era before newborn screening, less than half of cases of severe hypothyroidism were recognized in the first month of life. However, severe congenital hypothyroidism may cause the following serious signs and symptoms.
Most kids need to take the medicine for the rest of their lives. Testing for specific genetic mutations generally is only considered after other studies point to a specific hypothyoridism, e. Successful in utero treatment of fetal goitrous hypothyroidism: case report and review of the literature. Maternal autoimmune thyroid disease is relatively common, as approximately 5 percent of women of reproductive age have either anti-thyroglobulin or thyroid peroxidase antibodies [ 71 ]. MedlinePlus : Gene mutations causing congenital hypothyroidism can be a rare cause of distinct clinical phenotypes. Learning Disabilities.
What is congenital hypothyroidism?
The Annals of Pharmacotherapy. Cell surface receptor deficiencies. It is important to compare the serum results with age-normal reference ranges. A recent report showed that the incidence in the United States increased fromin toin [ 5 ].
It's thought that 10 to 20 percent of newborns who are hypothyroid have a temporary form of the condition known as treatment congenital hypothyroidism. Redrawn with permission after Netter FH. One of the signs of rickets is craniotabes, a softened outer table of the occipital bone that buckles under pressure, producing a reaction similar to a ping-pong ball indenting and popping back out. FZD4 Familial exudative vitreoretinopathy 1.
PTH1R Jansen's metaphyseal chondrodysplasia. Congenital hypothyroidism could occur in infants due to various reasons. Lyme disease. Cranial fasciitis of the anterior fontanel.
What is congenital hypothyroidism?
Sign Up. The overall goal of therapy is ensure that these patients are able to have growth and mental development that is as close as possible to their genetic potential. This study showed that noncompliance in adolescents is common, and that improvement in compliance and thyroid levels was associated with improved cognitive function. Genetic disorders relating to deficiencies of transcription factor or coregulators. Detection of thyrotropin binding inhibitory activity in neonatal blood spots.
New York: Macmillan, Boston: Little, Brown, In rare cases, the disorder may occur not due to a higher tsh values hypothyroidism in the thyroid hypothryoidism, rather due to inadequate stimulation from the pituitary gland. But eating certain foods may make your symptoms worse. One common cause of this is the presence of maternal antibodies that temporarily impair thyroid function for several weeks. Bridging of bone over a suture, an indistinct suture, or sclerosis along the suture margins indicates fusion. Affected babies may show no features of the condition, although some babies with congenital hypothyroidism are less active and sleep more than normal.
Treatemnt and Tools. Large fontanelle hypothyroidism treatment Center For Biotechnology Information. Common and chronic symptoms in pediatrics: a companion to the atlas of pediatric physical diagnosis. Treatment variables as predictors of intellectual outcome in children with congenital hypothyroidism. Louis: Mosby, Rarely, specific gene defects lead to central hypothyroidism. Etiology Permanent congenital hypothyroidism may be due to primary or secondary central causes.
Epidemiology Prior to the onset of newborn screening programs, the incidence of congenital hypothyroidism, as diagnosed after clinical ttreatment, was in the range of 1;7, to[ 1 ]. How to Tell if You Are Hypothyroid. Congenital hypothyroidism: Diagnostic algorithm. Although these results did not reach statistical significance, at the lower starting dose there was a trend toward a better IQ with earlier treatment, whereas with the higher starting dose, the IQ in early vs. Chromosomal abnormalities.
Anatomy of the Fontanels
Some babies with transient congenital hypothyroidism due to maternal medications during gestation may stop having levothyroxine once their thyroid gland produces adequate T4 hypothyroidism treatment. Additionally, eating more protein may help boost your metabolism. Signs and symptoms in pediatrics. The condition can be idiopathic or caused by hyperthyroidism, hypophosphatasia, rickets, or hyperparathyroidism. The goal of newborn screening programs is to detect and start treatment within the first 1—2 weeks of life.
In a study of hypothyroidism treatment year old adolescents with congenital hypothyroidism, the investigators made home visits lagge forewarning. Gene mutations causing congenital hypothyroidism can be a rare cause of distinct clinical phenotypes. Courtesy Dr. CASR Familial hypocalciuric hypercalcemia. This has not been a significant issue, however, as management of CH is based on restoring thyroid function to normal, not necessarily knowing the exact underlying cause. Thyroid hormone and attention in congenital hypothyroidism.
New York: Macmillan, VATER association vertebral defects, anal atresia, tracheoesophageal fistula, renal dysplasia. Congenital hypopituitarism. Craniosynostosis is the premature closing of one or more cranial sutures, resulting in an abnormal head shape. Nelson Textbook of pediatrics.
More on this topic for:
Most of these large fontanelle hypothyroidism treatment eventually ended up in institutional care. Hypothyroieism the anterior fontanel is open, ultrasonography is useful to evaluate ventricular dilatation. If treatment begins in the first two weeks after birth, infants usually develop normally. Your child can become dehydrated if they:. Your metabolism affects your body temperature and at what rate you burn calories.
Low thyroid levels during this treatmennt may result in irreversible damage, whereas the effects of hypothyroidism after age 3 years generally are reversible when corrected. Symptoms Symptoms of congenital hypothyroidism are initially nondescript; however, the maternal and pregnancy history may provide some clues. Manual of pediatric physical diagnosis. The length of time will depend on the results of testing and monitoring. Comparison between liquid and tablet formulations of levothyroxine in the initial treatment of congenital hypothyroidism. Dale J, Maurer PK. Emotional Problems.
Additionally, eating more protein may help boost your metabolism. Symptoms of hypothyroidism underactive thyroid can disrupt several parts of your life. Nard J. New York: Macmillan,
Earlier onset of treatment tgeatment increment in LT4 dose in screened congenital hypothyroidism: which as the more important factor for IQ at 7 years? In addition, New York found the incidence nearly double in twin births as compared to singletonsand even higher with multiple births Intracranial hemorrhage can be intraventricular, parenchymal, subarachnoid, or subdural. Thyroid ultrasonography can confirm a large gland, suggestive of dyshormonogenesis. Sadler TW, Langman J.
Growth and Development of the Skull
Cleidocranial dysostosis. Congenital hypopituitarism. Symptoms of congenital hypothyroidism are initially nondescript; however, the maternal and pregnancy history may provide some clues.
Skip to main content. Associated findings include decreased muscle tone, seizures, decreased hematocrit, vomiting, and alterations in consciousness. The blood is tested for amounts of hormones from the thyroid. These infants were then followed for growth and intellectual outcome at four years of age. These changes aid delivery through the birth canal and usually resolve after three to five days. In one study of infants with congenital hypothyroidism, extra thyroidal congenital malformations had a prevalence of 8.
Fontanels are the fibrous, membrane-covered gaps created when more than two cranial bones are trfatment, as opposed to sutures, which are narrow seams of fibrous connective tissue that separate the flat bones of the skull. Several screening programs have investigated psychometric outcome in relationship to severity of hypothyroidism, addressing the question of whether the most severely affected infants may have suffered prenatal damage that is not reversible even with early detection and treatment. How is congenital hypothyroidism diagnosed? Although levels of all hormones are higher at days of age, by weeks of age they have fallen closer to the levels typically seen in infancy. Neonatal hypothyroidism detected by the Northwest Regional Screening Program.
Growth and Development of the Skull
Dontanelle l-thyroxine is the treatment of choice. Secondary or central hypothyroidism at birth results from a deficiency of thyroid stimulating hormone TSH. Improved prognosis in congenital hypothyroidism treated before age three months. Some infants who undergo serum testing because of "low T4, non-elevated TSH" screening test results will be discovered to have thyroxine binding globulin TBG deficiency. Neither test approach will detect infants with defects of thyroid transport, metabolism, or action.
Psychometric testing showed a mean IQ of Large fontanelle hypothyroidism treatment defect in the enzyme iodotyrosine deiodinase which aids hypothyroiidsm the peripheral conversion of T4 to T3 has been shown in hypothyroid individuals. Malnutrition poor weight gain, asymmetric growth. Reprints are not available from the authors. Congenital hypothyroidism occurs when a newborn infant is born without the ability to make normal amounts of thyroid hormone.
J Clin Endocrinol Metab. Psychometric testing showed large fontanelle hypothyroidism treatment mean IQ of However, recent studies have shown an increase in the number of cases caused by gland in situ termed dyshormonogenesis when there is a defect in hormone production. Any associated dysmorphic facial features should be noted. It is important to note that the time for TSH normalization is inversely related to neurodevelopmental outcome [ 86 ]. Also know what the side effects are. Pendred syndrome - hypothyroidism- deafness - goiter Pendrin mutation.
Zellweger syndrome high forehead, flat occiput, abnormal ears, hypotonia. Hypoxic-ischemic encephalopathy. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP.
However, the last study also notes that children on high dose l-thyroxine treatment had significant problems with hyperactivity, delinquency and aggression [ 92 ]. Transient hypothyroidism in the newborn: to treat or not treatment treat. Examination at birth of an infant with craniosynostosis might reveal a ridge over a suture or lack of movement along a suture when alternating sides are gently pressed. As described under confirmatory serum thyroid testing aboveresults will lead to a diagnosis of primary congenital hypothyroidism, subclinical hypothyroidism, and, in some programs, secondary or central hypothyroidism. Brit Med J[ 13 ]. Skip to main content.
Views Read Edit View history. Lead encephalopathy. As mentioned above, it is normal for a baby's fontanelle to be slightly raised when they are crying or vomiting. As a result, people with hypothyroidism may experience tiredness, hair loss, weight gain, feeling cold, and feeling down, among many other symptoms 1. The most common causes of a large anterior fontanel or delayed fontanel closure are achondroplasia, hypothyroidism, Down syndrome, increased intracranial pressure, and rickets. Although the soft spot is a space between the skull bones, a tough membrane over the opening protects the soft tissue and the brain inside.
Hepatic encephalopathy. Structural brain defects. The hypothalamic-pituitary-thyroid values hypothyroidism feedback control axis in children with treated congenital hypothyroidism. Even most of those with athyreosis and undetectable T 4 levels at birth develop with normal intelligence, although as a population academic performance tends to be below that of siblings and mild learning problems occur in some. Children with congenital hypothyroidism and their siblings: do they really differ? MR has researched and written the sections on clinical features, etiology and management and built tables 2, 3, 4, and 6.
Definition and classification
Childs Nerv Syst. Sample meal plan. Read the Issue. Electrolyte disturbance.
People with hypothyroidism should avoid millet, processed foods, and supplements like selenium and zinc, unless a healthcare professional has advised otherwise. Spondylometaphyseal dysplasia, Sedaghatian type. Universal craniosynostosis. Surprisingly, many common foods contain goitrogens, including 21 :. Updated January Some babies may display symptoms days after birth.
Persistence of severe, untreated hypothyroidism resulted in severe mental impairment, with an IQ below 80 in the majority. Infants born with congenital hypothyroidism may show no effects, or may display mild effects that often go unrecognized as a problem: excessive sleepingreduced interest in nursingpoor muscle tonelow or hoarse cry, infrequent bowel movements, significant jaundiceand low body temperature. The expression of thyroid hormone receptors in human bone. Search Encyclopedia. The triangular posterior fontanel is located at the junction of the occipital and two parietal bones. At 32 weeks gestation, amniotic fluid TSH was 8.
Dermoid cyst. Thus, large fontanelle hypothyroidism treatment with iodine deficiency might be at risk treatmebt hypothyroidism People with hypothyroidism make less thyroid hormone. Nut butters are common choices on the keto diet because they're high in fat and protein. If your baby lies on their back to sleep and sits in a car seat for long stretches of time while awake, the back of their head can become flata condition known as positional plagiocephaly.
What causes congenital hypothyroidism?
The list above is a range of average closure times. Congenital endocrine disorders. MomJunction's health articles are written after analyzing various scientific reports and assertions from expert authors and institutions.
If the fetal thyroid hormone deficiency is severe because of complete absence athyreosis of the gland, treament features may include a larger anterior fontanelpersistence of a posterior fontanel, an umbilical herniaand a large tongue macroglossia. These mutations are dominantly inherited and affected individuals are generally euthyroid, however some hypothyroid individuals have been described. Transient congenital hypothyroidism is found to be more common in Europe than the United States[ 3 ]. Incidence and age at diagnosis.
High prevalence of thyroid peroxidase gene mutations in patients with thyroid dyshormonogenesis. If a newborn is not treated for congenital hypothyroidism, this can negatively impact physical, cognitive, and neurological development. Congenital absence of parathyroid. In addition, some programs also routinely obtain a 2 nd specimen between two and six weeks of age. Radionuclide uptake and scanning generally are the most accurate tests in defining some form of thyroid dysgenesis, e. Revised guidelines for neonatal screening programmes for primary congenital hypothyroidism. Or it can be caused by treatment of a thyroid problem while you are pregnant.
Most newborns with congenital hypothyroidism do not treatment any signs or symptoms of the condition. The primary emphasis of this review is a discussion of primary CH, but there also will be some discussion of secondary or central CH. In some cases, the thyroid gland may start working again. Early in the experience of screening, most programs undertook an initial T4 test, with a follow-up TSH test on infants below a specified T4 cutoff [ 2 ].
The information contained on this Web site should not be used as a substitute for the medical care and advice of your pediatrician. Diagnostic algorithm: the diagnosis of congenital hypothyroidism begins with either abnormal newborn screening test results or a clinical suspicion of hypothyroidism, leading to serum thyroid function tests typically TSH and free T4 to confirm the diagnosis. Our thyroid-friendly meal plan can help. Causes and Risk Factors of Thyroid Disease. This is important if your child becomes ill and you have questions or need advice.
By several years of age, they would display the recognizable facial and body features of cretinism. Such testing leads to the detection large fontanelle hypothyroidism treatment infants with "delayed TSH rise", which occurs in approximatelynewborns [ 64 ]. The information contained on this Web site should not be used as a substitute for the medical care and advice of your pediatrician. This term refers to an aberration of the embryological development of the thyroid gland. A novel NKX2. Cerebral malaria. Soy formula complicates management of congenital hypothyroidism.
Cleidocranial dysostosis. Most of these cases occur when one of several steps in the hormone synthesis process is impaired; these cases are classified as thyroid dyshormonogenesis. Dysmorphogenetic syndromes. Some babies may not be screened or develop symptoms of the disorder later.
Anatomy of the Fontanels
Looking at your newborn: what's normal. Green M. Bridging of bone over a suture, an indistinct suture, or sclerosis along the suture margins indicates fusion. Manual of pediatric physical diagnosis.
Abnormal hypothyroidism development that results in microcephaly also can cause a small anterior fontanel or early fontanel closure. By uypothyroidism years of age, they would display the recognizable facial and body features of cretinism. Make sure your child drinks all the liquid. An abnormal fontanel in an infant can indicate a serious medical condition. If these appear then serum testing of thyroid function should be performed and if inconclusive, these patients should be continued to be followed closely with a low threshold for re-testing.
These are based on fontanellw of TSH or thyroxine T 4 on the second or third day of life Heel prick. Reducing sudden infant death with "Back to Sleep. Taeusch HW, Sniderman S. Size is calculated by the average of the anteroposterior and transverse dimensions 9 Figure 2. Clinical signs of dehydration in children.
Prenatal trauma treatmeny the brain, such as maternal alcohol abuse, and postnatal trauma, such as hypoxia, are potential causes of microcephaly. The newborn's skull is molded during birth. However, recent studies have shown an increase in the number of cases caused by gland in situ termed dyshormonogenesis when there is a defect in hormone production.
These changes aid delivery through the birth canal and usually resolve after three to five days.
The newborn's skull is molded during birth. Craniotabes can occur normally in premature infants and in children younger than six months.
Infantile hydrocephalus: brain sonography as an effective tool for diagnosis and follow-up. Even when diagnosed early, neurologic development may suffer if treatment is not optimized in the first two to three years of life [ 81 ].
Address correspondence to Joseph Kiesler, M.
Hematologic disorders. Brain abscess. He graduated from and completed treamtent family medicine residency at the University of Cincinnati College of Medicine. Nongoitrous congenital hypothyroidism has been described as the "most prevalent inborn endocrine disorder". Other signs of dehydration include not producing enough urine, excessive sleepiness, irritability, dry mouth, and crying without tears. Boston: Little, Brown,
The slow development of obvious clinical symptoms [ 13 ], coupled with the importance of early treatment led to the implementation tdeatment widespread newborn screening for this condition [ 2 ]. Hydrocephalus can uypothyroidism from an imbalance between the production and the absorption of cerebral spinal fluid. Also, higher doses of l-thyroxine have been associated with higher intelligence quotients at 7 and 8 years of life, especially in the areas of verbal memory and verbal comprehension [ 92 ]. Congenital hypothyroidism is treated by giving thyroid hormone medication in a pill form called levothyroxine. This will help ensure a child reaches their normal adult height. Thus, we only recommend TRB-Ab determinations in a case where a previous child has had transient congenital hypothyroidism, and mother has known autoimmune thyroid disease and is pregnant again. Mutations in the dual oxidase maturation factor DUOXA2 gene also lead to deficient iodide organification through similar mechanisms and can cause partial iodide organification defects [ 49 ].
Philadelphia: Lippincott-Raven, Hypoxic-ischemic injury. The pituitary does not make sufficient thyroid-stimulating hormone, leading to inadequate secretion of thyroid hormones by the thyroid gland 5. Dysmorphogenetic syndromes.
Symptoms Symptoms of congenital hypothyroidism are initially nondescript; however, the maternal and pregnancy history may provide some clues. Autoimmune lymphoproliferative syndrome 1B. Infant with congenital hypothyroidism. In addition, there is some variation in the incidence among different racial and ethnic groups, and the mix of these groups has changed. Brain abscess.
Boston: Little, Brown, Neonatal hypothyroidism; Mount Sinai. People with hypothyroidism may often feel cold and fatigued and may gain weight easily. These cases are classified as thyroid dysgenesis. Congenital hypothyroidism. Brain tumor.
Diagnosing Hashimoto's Disease. It's also tested for amounts of hormones that tell the thyroid to make more hormones. Another form of TSH resistance is dominantly inherited and has been linked to the long arm of chromosome 15 [ 42 ].
Thyroid ectopia, athyreosis, hypoplasia, hemiagenesis.
Head Shape. Dale J, Maurer PK.
Duc G, Largo RH.
Other signs of dehydration include not producing enough urine, excessive sleepiness, irritability, dry mouth, and crying without tears.
Increased intracranial pressure.
Apert's syndrome craniosynostosis, proptosis, hypertension. It is now deprecated; ICD uses " congenital iodine deficiency syndrome " with additional specifiers for the various types. Intrauterine growth retardation birth weight less than 2 standard deviations below mean. The newborn infant. It makes iodine-containing hormones that play an important role in regulating growth, brain development, and the rate of chemical reactions in the body metabolism. Babies with the following conditions may have a higher risk of developing congenital hypothyroidism 3.
Lage disorders result in primary hypothyroidism. The key role of newborn thyroid scintigraphy with isotopic iodide I in defining and managing congenital hypothyroidism. HR Atrichia with papular lesions. Achondroplasia is an autosomal-dominant disorder of the epiphyseal plate cartilage that results in dwarfism. Electrolyte disturbance. On the other hand, all of the infants with milder hypothyroidism did well except the group treated with the lower dose and later age of onset, which had an IQ points lower than the other groups [ ].
Gene mutations causing congenital hypothyroidism can be a trdatment cause of distinct clinical phenotypes. Universal craniosynostosis. Treatment these results did not reach statistical significance, at the lower starting dose there was a trend toward a better IQ with earlier treatment, whereas with the higher starting dose, the IQ in early vs.
Cranial fasciitis of the anterior fontanel. This is called primary hypothyroidism and the most common type treatkent hypothyroidism. Premature fusing of the skull bones is a condition called craniosynostosis. Arch Pediatr Adolesc Med ;—1. As a result, people with hypothyroidism may experience tiredness, hair loss, weight gain, feeling cold, and feeling down, among many other symptoms 1. This can be a problem if you have hypothyroidism, as you may gain weight easily.
The developmental quotient DQ, as per Gesell Developmental Schedules of children with hypothyroidism at age 24 months that have received treatment hypothyrkidism the first 3 weeks of birth is summarised below: [ citation needed ]. However, once the bones grow to the point that they fill in the open spaces, the fontanelles are considered closed. On the first day of an infant's life, the normal fontanel ranges from 0. Also, cooking foods with goitrogens may inactivate these compounds This article explains whether you can use allulose on the keto diet. Thyroid hormone resistance syndrome. All newborns are screened for thyroid function through a heel-prick test blood collected from the heel before being discharged from the hospital or five days after birth.
A third fontanel between the anterior and posterior fontanels is associated with hypothyroidism and Down syndrome. Trisomy 13 polydactyly, microcephaly, cleft lip and palate. This condition affects 3 per 1, live births. Craniotabes can occur normally in premature infants and in children younger than six months. J Pediatr.
There are some advantages and disadvantages with each approach in the detection of other thyroid disorders. Want to use this article elsewhere? Abnormal head shapes in children: classifications and syndromes. Varma SK.
To see large fontanelle hypothyroidism treatment full article, hypothyoidism in or purchase access. Levothyroxine should be crushed and given once daily, mixed with a small amount of water, formula, or breast milk using a dropper or syringe. Hum Genet. Abnormal head shapes in children: classifications and syndromes. Thyroid disease. Low levels are indicative of hypothyroidism.
The thyroid gland will be tested hypothyroidism treatment time with blood tests. Sign up and get yours free! The developmental quotient DQ, as per Gesell Developmental Schedules of children with hypothyroidism at age 24 months that have received treatment within the first 3 weeks of birth is summarised below: [ citation needed ]. There is an inverse relationship between the starting l-thyroxine dose and the time to achieve the goal serum T4 concentration [ 85 ]. Family Life.
Symptoms of hypothyroidism underactive thyroid can disrupt several parts of your life. Intrauterine growth retardation birth weight less than 2 standard larfe below mean. A fontanelle can close earlier or later and still be normal. Large fontanelle hypothyroidism treatment hypoplasia is a form of thyroid dysgenesis see this term characterized by incomplete development of the thyroid gland that results in primary congenital hypothyroidism see this terma permanent thyroid deficiency that is present from birth. If your baby lies on their back to sleep and sits in a car seat for long stretches of time while awake, the back of their head can become flata condition known as positional plagiocephaly.
The thyroid gland makes thyroid hormones. Download as PDF Printable version.
Lyme disease. A soft spot that is abnormally large or does not close within the expected time frame can be a sign of certain medical conditions such as hypothyroidism, Down syndromeor rickets a condition caused by vitamin D deficiency.
Or it can be caused by treatment of a thyroid problem while you are pregnant. One case discovered by routine antenatal ultrasonography reported simultaneous amniotic fluid and fetal cord TSH measurements [ 78 ].
The pituitary does not make sufficient thyroid-stimulating hormone, leading to inadequate secretion of thyroid hormones by the thyroid gland 5.
Hypothyroidism treatment a thyroid-friendly diet can minimize your symptoms and fpntanelle you manage your weight. Babies with a missing thyroid gland or genetic syndrome may need synthetic thyroxine for the rest of their lives 8. Facts about craniosynostosis. Navigate this Article. Short-rib thoracic dysplasia 20 with polydactyly. How Is Congenital Hypothyroidism Diagnosed? Craniotabes is not present at birth but develops over the first few months of life.
Most babies are affected by the thyroid dysgenesis type of neonatal hypothyroidism. Cutting Out Calories a Day and Exercising Can Help You Stay Heart Healthy According to a new study, taking steps to eat fewer calories and working out daily can help your heart health, whether or not you lose weight. Table of Contents. If untreated for several months after birth, severe congenital hypothyroidism can lead to growth failure and permanent intellectual disability. Structural brain defects.