Iodine induced hypothyroidism occurrence and epidemiology and infection – Effects of drugs on thyroid function tests

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Risk of non-Hodgkin lymphoma and lymphoproliferative precursor diseases in US veterans with hepatitis C virus. Lacka K, Szeliga Epidemkology. The significance of nontoxic thyroid nodules: final report of a year study of the incidence of malignancy. The radiation dose was related to increased TPOAb prevalence, thereby suggesting that important clinical changes could appear gradually The most common cause of thyroid disorders worldwide is iodine deficiency, leading to goitre formation and hypothyroidism. Metals can behave both as endocrine disruptors, perturbing the hormonal system, and as carcinogens, promoting malignant transformation.

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Bogazzi, F. Thyroid function and prevalence of anti-thyroperoxidase antibodies in a population with borderline sufficient iodine intake: influences of age and sex. Enter your email address below and we will send you your username. Endocrine and Metabolic Agents. VAT will be added later in the checkout.

Management of amiodarone-related thyroid problems. Mazzarella, C. Iodine excess and hyperthyroidism. PowerPoint slides. Polska 632—9 Boelaert, K. PowerPoint slide for Table 2.

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The Danish investigation on iodine intake and thyroid disease, DanThyr: status and perspectives. Google Scholar 49 Biondi, B. PubMed Google Scholar. Sichieri, R. Connolly, R. Influence of dietary iodine on the iodine content of pork and the distribution of the trace element in the body. Zimmermannand Sophie E.

Different autoimmune diseases show low vitamin D levels, which are also associated with ATA, altered thyroid function, high thyroid volume, elevated TSH levels, and adverse pregnancy outcome in Inudced women. Polychlorinated biphenyls and their metabolites and polybrominated diethyl ethers bind to thyroid transport proteins, such as transthyretin, displace thyroxine, and disrupt thyroid function. AA and BS revised it critically for important intellectual content. Hypothyroidism has also been reported with sorafenib and imatinib treatments. Toxic Adenoma and Multinodular Toxic Goiter. Some patients have a combination of the two types of AIT and require both methimazole and corticosteroids.

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The epidemiology of thyroid disease. Fisher, D. Thyroid 17— JAMA—

  • The panel concludes that the evidence is insufficient to recommend for or against providing the service or intervention because evidence is lacking that the service or intervention improves important health outcomes, the evidence is of poor quality, or the evidence is conflicting.

  • Prevalence of thyroid disease, thyroid dysfunction and thyroid peroxidase antibodies in a large, unselected population. Characterization of thyroid abnormalities in a large cohort of children with Down syndrome.

  • GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Goitre and thyroid nodules.

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  • Natural history of the transition from euthyroidism to overt autoimmune hypo- or hyperthyroidism: a prospective study.

Mahzari, M. Pharmacologically induced thyreopathy in patients with cardiovascular disease. Change Password. Figures References Related Details.

ZamrazilR. Impact of Iodination on Thyroid Pathology in Africa. Comparative study of thyroid function and types of thyroid dysfunction in two areas in Denmark with slightly different iodine status. Persani, L. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Highly sensitive colorimetric sensor for detection of iodine ions using carboxylated chitosan—coated palladium nanozyme.

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Most patients with non-Hashimoto goiters are euthyroid or have hyperthyroidism, but goitrous hypothyroidism may occur in endemic goiter due to iodine deficiency. QJM — Risk of non-Hodgkin lymphoma and lymphoproliferative precursor diseases in US veterans with hepatitis C virus. Effects of manganese on thyroid hormone homeostasis: potential links.

Suppression of thyrotropin in the low-thyroxine state of severe nonthyroidal illness. Only one 82 of these studies was randomized and neither included a placebo group. This study was not population-based and did not distinguish between untreated subclinical hypothyroidism and undertreated overt hypothyroidism. Medications can also induce hyperthyroidism in patients with endemic iodine-deficient goiter, autonomous nodules, or non-toxic nodular goiter, or in patients recently treated with antithyroid drugs for GD. Smoking is negatively associated with the presence of thyroglobulin autoantibody and to a lesser degree with thyroid peroxidase autoantibody in serum: a population study. She says she also has had easy bruising with poor wound healing during this time. If iodine deficiency is severe, the patient becomes hypothyroid, a rare occurrence in the United States since the advent of iodized salt.

Thyroid Vol. Secondary hypothyroidism occurs when the hypothalamus produces insufficient thyrotropin -releasing hormone TRH or the pituitary produces insufficient TSH. Epiemiology the patient has signs or symptoms of cardiac disease, atrial fibrillation or other arrhythmia, or medical issues requiring urgent diagnosis and treatment, these tests should be performed within a shorter interval, particularly if there are signs or symptoms of hyperthyroidism. Thyroid Emergencies. Old Password.

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Indian J. Ross, D. Hypothyroidism: Should I take iodine supplements? Bogazzi, F.

A cautious iodization program bringing iodine intake to a low recommended level is associated with an increase in the prevalence of thyroid autoantibodies in the population. Endocrinology 6— Jessica FarebrotherMichael B. Cukier, P. Amiodarone and the thyroid. Google Scholar 97 Mazzarella, C. Risks and benefits of iodine supplementation.

Iodine Excess and Hyperthyroidism. See also Antidepressant withdrawal: Is there such a thing? Hypothyroidism symptoms: Can hypothyroidism cause eye problems? Iodine intake and the pattern of thyroid disorders: a comparative epidemiological study of thyroid abnormalities in the elderly in Iceland and in Jutland, Denmark. Prevention of iodine diseases in Ukraine. You usually don't need iodine supplements if you live in the United States or most developed countries. Iodine status as determined by urinary iodine excretion in Lesotho two years after introducing legislation on universal salt iodization.

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Intravenous Methimazole in the Treatment of Refractory Hyperthyroidism. Incidence of different forms of thyroid dysfunction and its degrees in an iodine sufficient area. Autoimmunity 1361—68

Endocrine side effects of cancer immunotherapy. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Show more related content. Thyroid Vol.

Well-conceived and executed intervention trials are needed to bring definitive data to light on these questions. Iodine supplementation of populations with mild-to-moderate iodine deficiency. Chronic hepatitis C virus infection: prevalence of extrahepatic manifestations and association with cryoglobulinemia in Bulgarian patients. Hewagama A, Richardson B. Returning user. Metabolism —

Bogazzi, F. Assessment of iodine nutrition in populations: past, present, and future. In the developed world, the prevalence of undiagnosed thyroid disease is likely falling owing to widespread thyroid function testing and relatively low thresholds for treatment initiation. Stanbury, J. Thyroid hormone therapy for older adults with subclinical hypothyroidism.

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Subject occurrehce. Data Synthesis The strength of the evidence that untreated subclinical thyroid disease is associated with clinical symptoms and adverse clinical outcomes was assessed and recommendations for clinical practice developed. RubioEduardo K. Use of iodine for water disinfection: iodine toxicity and maximum recommended dose. However, because of a possible association with increased cardiovascular mortality, 50 clinicians might consider treatment of elderly individuals, despite the absence of supportive data from intervention trials.

O'Leary, P. Figures References Related Details. Substances Iodine. The epidemiology of thyrotoxicosis in Denmark. Some alternative medicine specialists suggest iodine tablets or kelp supplements — which are high in iodine — for hypothyroidism. Taylor View author publications.

Investigation of thyroid dysfunction is more likely in patients with high psychological morbidity. New User. Login to your account Username. Mayo Clin. Forgot password?

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Prevalence of thyrotoxicosis, antithyroid medication use, and complications among pregnant women in the United States. Casey, B. Five-year follow-up in a large network of primary care physicians. Effect of excess iodine intake on thyroid diseases in different populations: A systematic review and meta-analyses including observational studies.

Acta Med. Delshad, H. Increased incidence of thyroid cancer in Latina, Italy: A possible role of detection of subclinical disease. Global epidemiology of hyperthyroidism and hypothyroidism.

Cerovskaand F. Expert Rev. Thyrotoxic periodic paralysis. Increased incidence of thyrotoxicosis in Malmo during the years — as compared to the years — Thyroid dysfunction in the elderly. Google Scholar Schultheiss, U. Google Scholar 20 Pierce, M.


Iodine intake and the pattern of thyroid disorders: a comparative epidemiological study of thyroid abnormalities in the elderly in Iceland and in Jutland, Denmark. Coma Depression and anxiety: Can I have both? How to heal cracked heels How to heal cracked skin at thumb tip Hypothyroidism and infertility: Any connection? Hypothyroidism symptoms: Can hypothyroidism cause eye problems? Thyroid 13—

Graves Disease Diffuse Hyperplasia. Toxic Adenoma and Multinodular Toxic Goiter. Article Contents Abstract. Privacy Policy. Whether untreated subclinical hypothyroidism affects important cardiovascular outcomes such as angina pectoris, myocardial infarction MIand cardiovascular death remains an unanswered question. Forgot your username?

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  • Diastolic dysfunction in patients on thyroid-stimulating hormone suppressive therapy with levothyroxine: beneficial effect of beta-blockade. Color-flow Doppler thyroid ultrasound may demonstrate increased blood flow in an enlarged, frequently nodular goiter type 1 AIT or decreased blood flow in a normal or small-sized thyroid type 2 AIT.

  • Diagnosis and management of amiodarone-induced thyrotoxicosis in Europe: results of an international survey among members of the European Thyroid Association.

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Tax calculation will be finalised during checkout. Ross, D. Disorders that cause hypothyroidism. The thyroid epidemiology, audit, and research study: thyroid dysfunction in the general population.

Effect of excess iodine intake on thyroid diseases in different populations: A systematic review and meta-analyses including observational studies. Drug-induced thyroid disorders. Bath, S. Lancet ,


Treatment of subclinical hypothyroidism or hypothyroxinemia in pregnancy. More studies are needed in developing countries, especially within Africa, to understand the role of ethnicity and iodine nutrition fluxes in current disease trends. Rights and permissions Reprints and Permissions. You can also search for this author in PubMed Google Scholar. Pattern of thyroid disorders in the southwestern region of Nigeria.

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  • Neurotoxicology 28 —6. Thyroid 7 —4.

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Zimmermannand Sophie E. VAT will be added later in the checkout. Iodine Supplementation. Gopinath, B. Are cytologic and histopathologic features of hot thyroid nodules different from cold thyroid nodules? Subclinical thyroid disease.

Toxic Nodular Goiter. Tobacco smoking and thyroid function: a population-based study. Development of thyroid dysfunction among women with excessive iodine intake — a 3-year follow-up. Low incidence rate of overt hypothyroidism compared with hyperthyroidism in an area with moderately low iodine intake.

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Assessment of thyroid function in children, adults and pregnant and lactating women after long-term salt iodisation measurements. Krassas, G. Iodoprophylaxis and thyroid autoimmunity: an update. Iodine deficiency in Europe anno

Iodine-induced thyrotoxicosis in Kivu, Zaire. Thyroid 883— Unnikrishnan, A. Walsh, J.

Figure 2: Map of overt hypothyroidism prevalence selective populations used when representative data not available. De Groot, L. Sign up now. Micronutrients and women of reproductive potential: required dietary intake and consequences of dietary deficienty or excess. Nippoldt, M. Trace iodine quantitation in biological samples by mass spectrometric methods.

Effects of long term iodized table salt consumption on serum T3, T4 and TSH in an iodine deficient area of Bangladesh. Urinary iodine concentration UIC could be a promising biomarker for predicting goiter among school-age children: A systematic review and meta-analysis. East Afr. Low dose oral iodized oil for control of iodine deficiency in children. Hypothyroxinemia and TPO-antibody positivity are risk factors for premature delivery: the generation R study.

Failure to find an association between hepatitis C virus and thyroid autoimmunity. The types of drug-induced hypothyroidism are:. Data relating restoration of the TSH level to within the reference range with improvements in bone mineral density were rated as fair.

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  • Thyroid 26— Incidence rate of symptomatic painless thyroiditis presenting with thyrotoxicosis in Denmark as evaluated by consecutive thyroid scintigraphies.

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  • Bone metabolism during antithyroid drug treatment of endogenous subclinical hyperthyroidism.

No increase in fracture incidence in patients treated for thyrotoxicosis in Malmo during a year population-based follow-up. Try out PMC Labs and tell us what you think. Amiodarone-induced thyroid dysfunction. Clin Endocrinol Oxf 79 — Amiodarone and the thyroid.

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Arch Otolaryngol Head Neck Surg — HCV interferes hypotbyroidism functions and self-recognition mechanisms in immune system or in thyrocytes leading to destruction of thyroid and beginning the autoimmune disease Cardiac Dysfunction, Arrhythmias, and Adverse Events. The spectrum of thyroid disease in a community: the Whickham survey. A low selenium concentration is associated with the appearance of AT or GD Hypothyroidism continues as long as amiodarone is given.

Neurotoxicology —6. Published by Oxford University Press. Am J Med. Comparison of second and third generation methods for measurement of serum thyrotropin in patients with overt hyperthyroidism, patients receiving thyroxine therapy and those with non-thyroidal illness. Thyroid cancer in HCV-related mixed cryoglobulinemia patients. Epidemiology of hepatitis C virus infection.

Female reproductive issues in multiple sclerosis. Epieemiology, most thyroid nodules are not clinically recognized. Other manifestations: Pleural or abdominal effusions pleural effusions develop slowly and only rarely cause respiratory or hemodynamic distresshoarse voice, and slow speech. Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of multiplex families.

  • Oxidoreductases, transferases, hydrolases, lyases, isomerases, ligases, glutamine synthetase, and Mn superoxide dismutase are Mn-containing enzymes. Cd in blood correlates with concentrations in the thyroid.

  • Kamilla G. Should both iodised and non-iodised salt be made available in Chinese cities?

  • Ocular manifestations: Periorbital swelling due to infiltration with the mucopolysaccharides hyaluronic acid and chondroitin sulfate, droopy eyelids because of decreased adrenergic drive. Rent this article from DeepDyve.

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  • Thyroid 20 — Treatment for amiodarone-induced hypothyroidism is LT4.

JAMA Intern. Konno, N. Schneeberg, N. Thyrotoxic periodic paralysis.

  • Effects of manganese on thyroid hormone homeostasis: potential links.

  • Extrathyroidal manifestations of Graves' disease: a update. Meyerovitch, J.

  • Ann Endocrinol Paris 71 — Non-surgical approach to the benign nodular goiter: new opportunities by recombinant human TSH-stimulated I-therapy.

  • Urinary iodine and stable isotope analysis to examine habitat influences on thyroid hormones among coastal dwelling American alligators.

  • In patients with secondary hypothyroidism, L-thyroxine should not be given until there is evidence of adequate cortisol secretion or cortisol therapy is givenbecause L-thyroxine could precipitate adrenal crisis.

We used the US Preventive Services Task Force criteria 96 for recommending a screening test, which requires evidence of effectiveness of early detection. Breastfeeding and maternal and infant iodine nutrition. Thyroid effects of endocrine disrupting chemicals. This effect is transient and has been reported primarily with high doses of glucocorticoids and intravenous dopamine or dobutamine.

Clinical judgment should dictate occurrence and epidemiology the suspected drug should be withdrawn and how the thyroid dysfunction should be further investigated and treated. AITD lead to an immune attack on the thyroid, whose mechanisms are still unclear. In slides of paraffin-embedded thyroid tissues from patients undergoing thyroidectomy, EVB19 DNA was revealed in thyrocytes or in lymphocytesparticularly in papillary TC PTCleading to hypothesize that EVB19 is implicated in thyroid carcinogenesis In addition to primary and secondary hypothyroidism, other conditions may cause decreased levels of total T4, such as euthyroid sick syndrome and serum thyroxine-binding globulin TBG deficiency. Context Patients with serum thyroid-stimulating hormone TSH levels outside the reference range and levels of free thyroxine FT 4 and triiodothyronine T 3 within the reference range are common in clinical practice. Effects of subclinical thyroid dysfunction on the heart.


Incidence and geographical variation in the Funen region — Tsang, W. Iodisation in displaced African populations. Treatment of subclinical hypothyroidism or hypothyroxinemia in pregnancy. Keep me logged in.

The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. These changes may occur in localized foci within the gland or in the process of nodule formation. Article Navigation. Significance of selenium in thyroid physiology and pathology.

Barbesino, G. Iodine is essential for thyroid function. Clin Endocrinol Oxf —9. Iodine excess as an environmental risk factor for autoimmune thyroid disease.

Epideiology contrast, a prospective cohort study demonstrated, in subjects at risk of developing AITD, that smoking was negatively associated with the presence of TPOAb 3536which was confirmed in population studies 37 — To reduce the risk to populations and also in each patient, it is necessary to comprehend the association between environmental agents and thyroid dysfunction. All rights reserved.

Mogensen, E. Nystrom, H. Thyrotoxicosis, Overview of Causes. Kalk, W. Hoogendoorn, E. ZamrazilR. Doubling in the use of thyroid hormone replacement therapy in Denmark: association to iodization of salt?

Iodine supplementation for preventing iodine deficiency disorders in children. Amiodarone and Thyroid Dysfunction. Paroxysmal atrial fibrillation precipitated by amiodarone-induced thyrotoxicosis five months after cessation of therapy. Hadlow, N.

As selenium is involved in regulation of cell cycle, a decreased concentration is also important in the development of thyroid cancer TC 28 Subclinical hyperthyroidism. Hypothyroidism in pregnancy and postpartum. Clin Endocrinol Oxf 40 — Cadmium effects on the thyroid gland.

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Tammaro, A. A review: Radiographic iodinated contrast media-induced thyroid dysfunction. Impact of iodination on thyroid pathology in Africa. Products and services.

Autoimmunity and thyroid function in patients with chronic active hepatitis treated with hypothyroidism occurrence and interferon alpha-2a. In the adequate-selenium county, the prevalence of pathological thyroid disorders subclinical hypothyroidism, hypothyroidism, AT, and enlarged thyroid was significantly lower than in the low-selenium county No appropriately powered prospective, randomized, controlled, double-blinded interventional trial of either levothyroxine therapy for subclinical hypothyroidism or anti-thyroid therapy for subclinical hyperthyroidism exists. In addition, in primary thyrocytes, after EVB19 NS1 transfection, positive regulatory domain zinc finger protein 1 upregulation was observed Barbesino, G. Clin Endocrinol — Goitre prevalence and thyroid abnormalities at ultrasonography: a comparative epidemiological study in two regions with slightly different iodine status.

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In chronic Cd toxicity, multinodular goiter, thyroglobulin hyposecretion, and parafollicular cell hyperplasia are frequent Hyper- and hypothyroidism, boxing slow reflexes and hypothyroidism in AITD, are associated with bacterial overgrowth in small intestinal or with changes in composition of microbiota Serum thyroid-stimulating hormone measurement is the most sensitive test for diagnosing hypothyroidism. Nat Rev Endocrinol 6 — Different autoimmune diseases show low vitamin D levels, which are also associated with ATA, altered thyroid function, high thyroid volume, elevated TSH levels, and adverse pregnancy outcome in AITD women. Open Next post in Endocrinology Metabolism Close.

Am J Hum Genet — The authors concluded that the short-term l -selenomethionine supplementation has a restricted impact on the natural course in euthyroid HT. Infection and Autoimmune Thyroid Disease. Curr Opin Endocrinol Diabetes. Metals can behave both as endocrine disruptors, perturbing the hormonal system, and as carcinogens, promoting malignant transformation. Hypoglycemia is common because of concomitant adrenal insufficiency or growth hormone deficiency. Physicians and patients should understand the natural history of subclinical hypothyroidism and the small but definite risk of progression to overt hypothyroidism.

MkhitarovKathleen M. Thyroid Physiology. Lee, S.

When evidence was not available, was contradictory, or was judged to be insufficient, the panelists relied on their experience, judgment, epidemiologt interpretation of the available literature in formulating recommendations for clinical practice. Receive exclusive offers and updates from Oxford Academic. Google Scholar. Extrahepatic replication of HCV: insights into clinical manifestations and biological consequences. Whole grain rice fortification as a solution to micronutrient deficiency: Technologies and need for more viable alternatives. The incidence of IFN-induced hypothyroidism is increased with combined ribavirine treatment and in subjects with preexisting thyroid autoantibodies.

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Korevaar, T. Disturbances of thyroid function in adult population of the city of Cracow followed up for ten years observation [Polish]. Evaluation of iodine levels in the Riverina population. Risks and benefits of iodine supplementation. Iodine intake and the pattern of thyroid disorders: a comparative epidemiological study of thyroid abnormalities in the elderly in Iceland and in Jutland, Denmark.

Evidence of a geographic variation in frequency. Sustaining iodine deficiency disorders IDD control programme. South Afr. Highly sensitive colorimetric sensor for detection of iodine ions using carboxylated chitosan—coated palladium nanozyme.

Human T-cell lymphotropic epideniology, herpes simplex virus, rubella, mumps virus, Epstein—Barr virus, enterovirus in HT, retroviruses [human T-cell lymphotropic virus-1, human foamy virus or human immunodeficiency virus HIVand Simian virus 40] in GD have been shown Therefore, serum T3 is not sensitive for hypothyroidism. Show More. Constant iodine prophylaxis and increased iodine intake gradually reduce iodine deficiency-related thyroid disorders IIH may also occur with an increase in iodine intake in those whose hyperthyroidism Graves' disease is not expressed because of iodine deficiency.