Hypothyroidism

Hypothyroidism and endometrial hyperplasia after menopause – A Large Cohort Study of Hypothyroidism and Hyperthyroidism in Relation to Gynecologic Cancers

While these two conditions have very similar sounding names, they are in fact different.

Thyroid disorders in polycystic ovarian syndrome subjects: a tertiary hospital based cross-sectional study from eastern india. Journal overview. Brentani, and C. View at: Google Scholar J. How is endometrial hyperplasia managed or treated? In alternate analyses of cases of stage 1A to IVB, results were similar data not shown ; thus, these analyses focused on the invasive cancers of stages IB to IVB, which are of greater clinical and public health significance.

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  • In the middle of the cycle, an egg is released from one of the ovaries ovulation.

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Progesterone : A female hormone that is made in the ovaries and prepares endomwtrial lining of the uterus for pregnancy. Theories suggest that these benefits of exercise are due to a boost in immunity and increased removal of toxins, viruses and bacteria, all of which can trigger inflammation, hormonal imbalances and illnesses. Clinical Trials Information. Proliferative processes increase the thickness of the endometrium and lead to an increase in the volume of the uterine body.

  • For EC, at baseline and during followup, we excluded women who reported a hysterectomy from contributing person-time. Unusual vaginal discharge.

  • There are many causes of abnormal uterine bleeding. They are divided into 3 basic categories: Simple hyperplasia Complex hyperplasia Simple Hyperplasia with Atypia Endometrial Hyperplasia with Atypia Simple Hyperplasia Simple, or basic endometrial hyperplasia is generally considered benign, or minimal risk.

  • Age-adjusted and multivariable adjusted analyses were similar.

  • A previous immunohistochemical study, according to our evidence, reported a stronger ERs and PRs expressions in glandular epithelium of polyps than in glandular epithelium of adjacent endometrium. The appearance of THs in the supernatant of endometrial interstitial cells and Ishikawa cells indicated that they are secreted by endometrial cells.

  • The endometrium may continue to grow in response to estrogen. Preclinical data has identified a class of cell surface receptors in the endometrium that bind thyroid hormone directly and expression is correlated with infertility and implantation defects [ 41 — 43 ].

  • View at: Google Scholar M. Ovulation : The time when an ovary releases an egg.

They contain estrogen along with progestin. Best Value! Ridgway, C. Try out PMC Labs and tell us what you think.

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Hypothyroidism and endometrial hyperplasia after menopause type of endometrial hyperplasia endomehrial I have? Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. J Obstet Gynaecol India. Differential diagnosis For differential diagnosis, the doctor should be convinced of the absence of common systemic diseases, the symptomatic complex that is accompanied by uterine bleeding: hematologic diseases, liver, thyroid, and adrenal pathologies. Is It Serious? X-ray of the uterus and ovaries.

Thyroid uyperplasia. Asymptomatic cervical polyps: can we just let them be? Polyps are usually benign hypothyroidism and endometrial hyperplasia after menopause of normal tissue from the womb lining, and form in a mushroom shape of various sizes, attached to the lining by a stalk. Updated March 27, Cart Item Removed. Brighten Shop Book. According to homeopathic doctors, the failure in the work of these organs and systems is the most common cause of the appearance of endometrial hyperplasia in menopause.

If you have further questions, contact your ob-gyn.

Women with prolonged exposure to higher levels of thyroxine, as seen with hyperthyroidism, may be at risk for developing endometrial hyperplasia and EC by direct binding and proliferation, but further research is needed to investigate this association. The appearance of THs in the supernatant of endometrial interstitial cells and Ishikawa cells indicated that they are secreted by endometrial cells. La Vecchia, E.

  • Duffy, and P.

  • Medical disorders associated with endometrial carcinoma. The Gerson Diet consists of eating only organic fruits, vegetables and sprouted ancient grains; detoxifying with the use of coffee enemas ; consuming vegetable juices multiple times daily along with beef liver for added nutrients; and taking beneficial supplements.

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Several in vitro and in hypothyroidism and endometrial hyperplasia after menopause studies have implicated thyroid hormones in tumorigenesis and cell proliferation in glioma, gastric, and breast cancer cell lines [ 21 ]. When your endometrium thickens, it can lead to unusual bleeding. Results In the interval time considered 52 patients agreed to participate in the study but only 22 were eligible. Predictive power of sexual hormones and tumor markers in endometrial cancer. Also called the womb. Your menstrual cycle relies primarily on the hormones estrogen and progesterone.

Study Findings. A transvaginal ultrasound exam may be done to measure the thickness of the endometrium. In fact, in some cases of significant atypical hyperplasia, a very early stage endometrial cancer may already be present. During menopause, any uterine bleeding or spotting from the vaginaregardless of their volume abundant or meagerduration and frequency should be perceived as an alarm and a possible symptom of a malignant process. If anyone in your family has HNPCC or if you've been diagnosed with it, talk to your doctor about cancer screenings you should undergo. Transvaginal Ultrasound Exam : A type of ultrasound in which the device is placed in your vagina. Sometimes, during a conversation, the presence of abnormalities is detected.

  • Gallbladder disease. How is it diagnosed?

  • A hysterectomy is a surgery to remove the uterus.

  • Polycystic ovary syndrome PCOS. Won, E.

  • Indirectly, alterations in thyroid hormone levels cause changes in serum levels of sex hormone binding globulin SHBGsex hormones estrogen and testosteroneand their metabolism and clearance from the body [ 1718 ]. Price, H.

Price, H. The prevalence rates of hypothyroidism and subclinical hypothyroidism are 0. Email Alerts Don't miss a single issue. Don't have an ob-gyn? Cheung et al. This association has recently been clarified after a membrane cell surface receptor for thyroid hormones was characterized on rapidly dividing cells e.

Feelings and Cancer. Because the vagina is dry it may feel itchy, and friction can cause the cells to be rubbed away, exposing underlying blood vessels that may bleed. Medications used for conservative treatment of endometrial hyperplasia in menopause are hormone-containing drugs. What is the best treatment for the type of endometrial hyperplasia I have? Persimmon has antiviral properties. Enable All Save Changes.

Obstetrics and Gynecology International

Axe on Facebook 1 Dr. Women who have atypical endometrial hyperplasia have a higher risk of developing uterine cancer. Get Access. Side Effects of Cancer Treatment. What type of endometrial hyperplasia do I have?

Hyperrplasia endometrium refers to the time during the menstrual cycle when a layer of cells is being prepared for a fertilized egg to attach to…. What are the types of endometrial hyperplasia? During the first part of the cycle, the hormone estrogen is made by the ovaries. In this manner, leptin and its receptor might be important risk factors to be considered in EC. Topics: Diseases and Conditions Menstrual Health.

The ovaries express estrogen, progesterone, and thyroid hyperplasia after however, their complex interactions are not fully understood and the impact on cancer development, if any, remains unclear [ 7 atfer, 44 ]. There are two main types of endometrial hyperplasia, depending on whether they involve unusual cells, known as atypia. This is the layer of cells that line the inside of your uterus. Arch Gynecol Obstet4 : Cancer3 : How much and how long you take it depends on your age and the type of hyperplasia. Get Permissions.

If you have further questions, contact your ob-gyn.

How do I know if I have it? Endomtrial, D. Not enough cases were available for analyses of the alternative definition for hyperthyroidism. J Clin Endocrinol Metab89 7 : If you have abnormal bleeding and you are 35 years or older, or if you are younger than 35 years and your abnormal bleeding has not been helped by medication, your health care provider may perform diagnostic tests for endometrial hyperplasia and cancer.

J Assoc Physicians India49 : hyperplasia after menopause A possible hypothesis is that TR and ER bind two parts of the same hormone afetr elements of a target gene and can compete with each other. Based on this finding, TSH might be associated with systemic processes that interact with carcinogenesis e. Measures of thyroid-stimulating hormone TSHtotal thyroxine TT4and free thyroxine FT4 are the first-line diagnostic tests for hypothyroidism. Cell Physiol Biochem34 5

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Yamamura, S. Rui, and G. If you use hormone therapy after menopause, be sure that it includes progesterone. Progestin therapy can ease symptoms. Thyroid hormone receptors and reproduction.

This is why working with an experienced hypothroidism and having your therapy monitored is so important. More posts like this. Due to declining levels of estrogen, women over hypothyroidism and endometrial hyperplasia after menopause are unlikely to experience endometrial overgrowth. Research suggests that it can contribute to the strength and growth of muscles by increasing production of muscle cells. Risk factors for cardiovascular disease in women with subclinical hypothyroidism. Prevention How can I prevent endometrial hyperplasia? Proliferative processes increase the thickness of the endometrium and lead to an increase in the volume of the uterine body.

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Clin Exp Obstet Gynecol, 41 5 : Ann N Y Acad Sci, 1 : I understand your hesitancy to taking the prescription progesterone.

A trained nutritional biochemist and Naturopathic Physician, Dr. Clinical Trials during Coronavirus. A scraping procedure is performed under one of the types of anesthesia - local, epidural or general. Postmenopausal endometrial hyperplasia: role of danazol therapy. Progesterone prepares the endometrium to receive and nourish a fertilized egg.

About the Journal. Menstrual cycles that are shorter than 21 days counting from the first day of the menstrual period to the first day of the next menstrual period. Thyroid stimulating hormone, independent of thyroid hormone, can elevate the serum total cholesterol level in patients with coronary heart disease: a cross-sectional design. Conditions that are linked to anovulation lack of ovulation or oligomenorrhea in frequent periods like polycystic ovarian syndrome PCOS or undiagnosed thyroid issues can put women at greater risk. Prevention Knowing what endometrial hyperplasia is dangerous in menopause, you can make a plan for preventive measures, since the pathological process can be asymptomatic. Cancer Prevention Overview.

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That gets your period started and the cycle begins again. Rui, and G. Soares, and D.

With hysteroscopy, menopajse provider can see abnormalities within the endometrial cavity and take a targeted directed biopsy of any suspicious areas. It is not intended as a statement of the standard of care. If you have EIN changes in the lining, the risk of cancer is increased. The results of our pilot study, even if obtained in a small number of cases, confirm the expected different ERs pathway in postmenopausal women with large benign EPs linked to hypothyroidism and THs replacement therapy. J Assoc Physicians India49 :

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Epithelial hyperplasia is when cells overgrow in the lining of the ducts of the milk glands called lobuleswhich can sometimes increase the risk for breast cancer. Thyroid hormone receptors and reproduction. Endometrial atrophy is where the womb lining is very thinned. Factors affecting the risk of developing endometrial cancer include:. Metastatic Cancer Research. Vaginal and vulvar atrophy is caused by cellular changes during menopause.

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. You should call your healthcare provider if you experience: Heavy or abnormal bleeding. Mammography - X-ray after menopause of mammary glands to exclude proliferative processes. There is a lot of information out there about hyperplasia — some accurate and some not so accurate. Typically, postmenopausal women who experience bleeding are referred for further testing to either rule out or diagnose endometrial cancer. If ovulation does not occur, progesterone is not made and the womb lining will not shed. Hormone replacement therapy in postmenopausal women: endometrial hyperplasia and irregular bleeding.

If you have further questions, contact your ob-gyn. Typically, estrogen levels hypothyrodiism challenged by progesterone during the luteal phase, which prevents estrogen from going overboard with driving tissue growth. Unlike many hypothyroidism and endometrial hyperplasia after menopause cancer types, the rate of endometrial cancer has increased in recent years and is expected to continue rising worldwide over the coming decade. The glandular- cystic form is a more serious pathology in which not only an increase in the growth of glandulocytes is observed, but also the appearance of cystic formations in the inner layer of the uterine body. Postmenopausal bleeding should be referred urgently.

Diagnosed With Endometrial Hyperplasia

If you have any of these conditions and they are not under hypotuyroidism, getting them under control may help. This is the how obesity contributes to elevated circulating levels of estrogen and increases the risk of endometrial hyperplasia. While these two conditions have very similar sounding names, they are in fact different. Endometrial hyperplasia is rare.

The main complication is the risk that it will progress to uterine cancer. Get Permissions. Several hypoyhyroidism vitro and in vivo studies have implicated thyroid hormones in tumorigenesis and cell proliferation in glioma, gastric, and breast cancer cell lines [ 21 ]. Some researchers have investigated the relationship between hypothyroidism and the present known risk factors for EC.

Cancer, 6 : The majority of women with endometrial hyperplasia are able to manage their condition and often achieve regression, even with non-invasive therapies. Complications arising from endometrial hyperplasia in the menopausal period: recurrent course despite competent therapy, the disease has the property of recurrence ; problems with the genitourinary system neoplasms can squeeze adjacent organs, resulting in acute urinary retention and disruption of its normal outflow ; risk of malignization of the process of hyperplastic state of endometrial tissue; anemic conditions uterine bleeding can be quite abundant, resulting in a significant decrease in hemoglobin in the bloodstream. Long history of irregular or absent menstruation. To learn how to optimize estrogen naturally using nutrition and lifestyle with the free hormone starter kit.

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Gubbay, A. J Clin Endocrinol Metab90 7 Gardner, S. Hypothyroidism is closely related to infertility. The risk that cancer will come back after treatment is highest during this time.

  • Perimenopause : The time period leading up to menopause.

  • There is some suggestion that endometrial cancers happen more often in people who are overweight, so losing weight may also help. Natural therapies can either be used by themselves in some cases or in conjunction with conventional medical treatments to support the body in the healing process.

  • Introduction Endometrial cancer EC is the most common gynecologic malignancy in the United States, and the fourth most common cancer overall in women [ 1 ].

  • If you have EIN changes in the lining, the risk of cancer is increased. Well established risk factors for EC are hormonally linked and include a greater lifetime exposure to estrogen, obesity, and diabetes and display a progression from atypical hyperplasia to cancer [ 56 ].

All the best and God bless. There is some suggestion that endometrial cancers happen more often in people who are overweight, so losing weight may also help. Research Funding Opportunities. If you have further questions, contact your ob-gyn. Viewed Full text.

Moroni, C. The mechanism of action of hypothyroidism on infertility hypotyyroidism unknown. Nevertheless, hypothyroidism is more common in women with fertility problems. Therefore, hypothyroidism has been reported to induce menstrual and fertility problems, which tend to complicate amenorrhea and ovulation dysfunctions that are in turn also risk factors for EC. How is it diagnosed?

Examining Endometrial Cancer Worldwide

A large cohort study of hypothyroidism and hyperthyroidism in relation to gynecologic cancers. The most common sign of hyperplasia is abnormal uterine bleeding. Fertil Steril95 1 : Indian J Endocrinol Metab,17,217 2 :

All types of hyperplasia can cause abnormal and heavy bleeding that can make you anemic. View All. Hyperplasia of the endometrium is a proliferation, thickening and thickening of the mucous tissue of the uterus body, preventing the normal functioning of the reproductive system. Axe on Youtube Dr. Can Hyperplasia Become Cancerous? Your doctor may refer to this as endometrial intraepithelial neoplasia EIN. NCI Congressional Justification.

The aim of the study was to investigate the possible overexpression anc estrogen ERs and progesterone PRs receptors both in EPs glandular and stromal cells in postmenopausal women with levothyroxine-treated hypothyroidism in comparison to EPs detected in women with physiological thyroid hormone levels. Gynecol Oncol1 : The uterine lining is called the endometrium. Long history of irregular or absent menstruation.

Endometrial Hyperplasia Symptoms

Cancer Prevention Research. This procedure is known as dilation and curettage. Cancer Research Workforce. Praise Media My Account. How Is Endometrial Hyperplasia Diagnosed?

Doody, D. Ridgway, C. Rosenberg, F. Lindeberg, B. We will investigate stromal and glandular ERs and PRs expressions in EPs, peripheral and distant endometria in respect to polypoid tissue.

Many women find relief through progestin hormone treatments. FDA Approvals. Axe on Instagram K Followers. Endometrial hyperplasia usually occurs after menopause, when ovulation stops and progesterone is no longer made. If necessary, hysteroscopy is performed.

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A diet to reduce the inflammation that can trigger hyperplasia includes plenty of cancer-fighting foodssuch as:. How common is endometrial hyperplasia? The method is based on pulling the endometrial tissue site by the apparatus. Should I look out for signs of complications?

The atypical form adenomatosis is diffuse or focal. For the development of endometrial hyperplasia, the duration and dose of estrogen is important. It allows visual inspection of the inner walls of the uterine cavity to reveal common and focal pathological processes. Questions to Ask about Your Treatment.

Smear test for the presence of atypical cells. Differential diagnosis For differential diagnosis, the hpyerplasia should be convinced of the absence of common systemic diseases, the symptomatic complex that is accompanied by uterine bleeding: hematologic diseases, liver, thyroid, and adrenal pathologies. Article continues below Advertisement. Without treatment, your risk of endometrial or uterine cancer increases. Article Sources. Cancer Training at NCI. What type of endometrial hyperplasia do I have?

It offers current information and opinions related to women's health. J Reprod Immunol, 90 1 : Sometimes hormone replacement therapy is used — endometrisl as progesterone cream or hormones given orally, topically as a vaginal cream, in an injection or with an intrauterine device — while in other cases require removal of an organ. American Cancer Society. Specialists-herbalists in the treatment of endometrial hyperplasia in menopause suggest using both individual plants and herbal preparations.

What is endometrial (uterine) cancer?

Many types can go undetected for a period of time due to showing no symptoms like in the breast, for examplebut other forms might cause symptoms, including:. Endometrial adenocarcinoma, endometrioid type, well differentiated—cancerous changes in the lining. Research Funding Opportunities. This starter pack is exactly what every woman needs to bring her hormones back into balance! Cells are the building blocks for all parts of the body.

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References Munro, M. Hysteroscopy: Your provider uses a thin, lighted tool called a hysteroscope to examine the cervix and look inside the uterus. Certain steps may reduce your chances of developing endometrial hyperplasia: Use progesterone along with estrogen after menopause if you use hormone therapy. Read More. Certain types of hyperplasia can increase your risk for developing cancer, but not all do.

Cell Physiol Biochem, 34 5 We do not endorse non-Cleveland Clinic products or services. About The Author Dr. This website uses Facebook cookies to deliver advertisements to you when you are on Facebook or a digital platform powered by Facebook after visiting this website. Axe on Facebook 2.

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Thyroid function and TSH levels may become tumor markers to evaluate the prognosis and facilitate follow-up monitoring of patients with EC. Endometrial hyperplasia is a condition that causes abnormal uterine bleeding. These symptoms can be uncomfortable and disruptive. Cervical cancer starts in the cervix the neck of the uterus. Cell Physiol Biochem34 5

Thus, patients with EC tend to have hypothyroidism, suggesting that thyroid function and hormones might be related to EC; this relationship should be explored in greater detail. For all patients the following laboratory and clinical parameters were evaluated: age, weight, BMI, parity, sonographical and hysteroscopic size of the EPs, and TSH serum levels before polypectomy. Simple or complex atypical endometrial hyperplasia: An overgrowth of abnormal cells causes this precancerous condition. If you use hormone therapy after menopause, be sure that it includes progesterone. Hysterectomy may be a treatment option if you do not want another pregnancy. Hardefeldt, G. What is endometrial uterine cancer?

Nutr Metab, 9 1 : Among the factors that provoke endometrial hyperplasia in menopause, endonetrial note heredity, transferred inflammatory processes of the reproductive system, abortion, the use of oral and intrauterine contraceptives, endocrine pathologies that cause changes in the hormonal background of the entire female body and the menstrual cycle, in particular. Due to declining levels of estrogen, women over 65 are unlikely to experience endometrial overgrowth. The main emphasis in selecting a homeopathic drug in the treatment of hyperplasia should be directed to restoring the hormonal background, stabilizing the nervous system and improving the functioning of the liver.

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Well established risk factors for EC are hormonally linked and include a greater lifetime exposure to estrogen, obesity, and diabetes and display a progression from atypical hyperplasia to cancer [ 56 ]. You should call your healthcare provider if you experience: Heavy or abnormal bleeding. Women with prolonged exposure to higher levels of thyroxine, as seen with hyperthyroidism, may be at risk for developing endometrial hyperplasia and EC by direct binding and proliferation, but further research is needed to investigate this association. The prevalence of EPs appears to increase with age, and it is reported that more postmenopausal Endometrial hyperplasia is a condition of the female reproductive system.

Int J Gynecol Cancer, 25 5 : Endometrial Hyperplasia Endometrial hyperplasia nedometrial the uterus lining, causing heavy or abnormal bleeding. Excess estrogen can be reduced when we focus on supporting the liver in processing estrogen and helping the gut to eliminate it. Among the studies included in the analysis, the risk of endometrial cancer in women with postmenopausal bleeding was lower in studies that included women using hormone replacement therapy. Cell Physiol Biochem, 34 5

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Biopsy: An endometrial biopsy removes tissue samples from the uterus lining. The progesterone drop triggers the uterus to shed its lining as a menstrual period. Email Alerts Don't miss a single issue. The prevalence rates of hypothyroidism and subclinical hypothyroidism are 0. Concerning histological features of EPs, in Group A, 4 were functional and 8 atrophic, while in Group B, 3 were functional and the remaining 7 were atrophic.

The vagina leads from the uterus to the hypothyroidism and endometrial hyperplasia after menopause of the body. Article Sources. All types of hyperplasia can cause abnormal and heavy bleeding that can make you anemic. It should be noted that alternative methods can aggravate a woman's condition, lead to a loss of time to start effective treatment and provoke the development of dangerous complications. Since excess estrogen is usually involved with this condition, the typical conventional treatment for simple hyperplasia is progestin, which is a synthetic form of progesterone, or bioidentical progesterone. If ovulation does not occur, progesterone is not made and the womb lining will not shed.

Brentani, and C. S5—S15, Saccardi, C. Results A history of hyperthyroidism was rare, with 0.

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Endometrial hyperplasia is rare. Article continues below Advertisement. Br J Cancer98 1 : Daw, and W.

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  • Progestin : A synthetic form of progesterone that is similar to the hormone made naturally by the body. Endometrial Hyperplasia Biopsy If the ultrasound shows an abnormally thick uterine lining, your doctor may then order a biopsy.

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Research shows that even though hormone therapy might help control symptoms of PMS or menopausethey can increase the odds of mneopause cancer of the reproductive organs. It rarely occurs in women younger than Study Findings. Asymptomatic cervical polyps: can we just let them be? Rare Cancers of Childhood Treatment. All types of hyperplasia can cause abnormal and heavy bleeding that can make you anemic.

Cancer Health Disparities. The incidence rates of endometrial hyperplasia and endometrial cancer: a four-year population-based study. Choices for Care. The most popular homeopathic preparations in the treatment of hyperplastic states of the endometrium are:. A trained nutritional biochemist and Naturopathic Physician, Dr.

Progestin tsh 1 9 hypothyroidism in men given orally, in a shot, in an intrauterine device IUDor as a vaginal cream. This is called a hysterectomy. Siriwan et al. View at: Google Scholar F. J Endocrinol1 : Only one record-linkage analysis has examined the relationships of uterine and ovarian cancer risk with pre-existing chronic conditions and reported that thyroid diseases types of disease were not specified were associated with a significant risk of EC RR 1.

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